Sökning: "Marek Kwiatkowski"

Hittade 2 avhandlingar innehållade orden Marek Kwiatkowski.

1. 1. Studies on oligoribonucleotide (RNA) chemistry

   Författare :Marek Kwiatkowski; Uppsala universitet; []
   Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

   Sammanfattning : .... LÄS MER

3. 2. Novel Methods for Synthesis of High Quality Oligonucleotides

   Författare :Andrey Semenyuk; Marek Kwiatkowski; Ulf Landegren; Joachim W. Engels; Uppsala universitet; []
   Nyckelord :Organic chemistry; oligonucleotide; solid-phase synthesis; RNA synthesis; phosphoramidite; abasic sites; depurination; 2 -O-DTM; protecting group; cartridge; conjugate; dithiomethyl linker; base-stable linker; oligonucleotide purification; nucleoside; Organisk kemi;

   Sammanfattning : The first part of the work describes a procedure of oligonucleotide purification using a reversed-phase cartridge. The developed method employs a very efficient yet mild oligonucleotide detritylation on the cartridge support allowing fast purification of oligonucleotides regardless of their 5´-modification. LÄS MER