Sökning: "LRIG1-3"

Hittade 3 avhandlingar innehållade ordet LRIG1-3.

1. 1. Leucine-rich repeats and immunoglobulin-like domain (LRIG) proteins : possible prognostic markers in vulvar squamous cell carcinoma, endometrial carcinoma, and oropharymgeal squamous cell carcinoma

   Författare :Husam Oda; David Lindquist; Eva Lundin; Ulrika Ottander; Kristina Stefansson; Kate Cuschieri; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vulvar squamous cell carcinoma; endometrial carcinoma; oropharyngeal squamous cell carcinoma; LRIG1-3; HPV; LMO7; HPV-driven; non-HPV-driven; prognosis; overall survival; disease-free survival; p53; Ki-67; CD8 TILs; CD44.; Pathology; patologi;

   Sammanfattning : The human leucine-rich repeats and immunoglobulin-like domain (LRIG) gene family comprises three genes, LRIG1, LRIG2 and LRIG3, which encode the LRIG1, LRIG2 and LRIG3 proteins, respectively. Previous stidies have revealed the different prognostic roles of these proteins in different cancers, and it has been shown that LRIG1 functions as a tumour suppressor in certain cancers via its negative regulation of several receptor tyrosine kinases. LÄS MER

3. 2. The Identification and Characterisation of LRIG Gene Family and Its Expression in Astrocytic Tumours

   Författare :Dongsheng Guo; Tomas Ekström; Umeå universitet; []
   Nyckelord :astrocytoma; brain; EGFR; LRIG; leucine-rich repeat; real-time RT-PCR; onkologi; Oncology;

   Sammanfattning : Gliomas are the most common primary brain tumours, and their capacity to invade surrounding normal brain prevents complete removal of the tumour. Malignant glioma has still a poor prognosis. However, with the rapid development of molecular biology our understanding about glioma has increased dramatically. LÄS MER

4. 3. Oesophageal Cancer – Novel Targets for Therapy : With focus on Hsp90, EGFR, LRIG, microtubule and telomerase

   Författare :Xuping Wu; Simon Ekman; Johan Lennartsson; Ylva Pausson-Karlsson; Michael Bergqvist; Joachim Gullbo; Stefan Bergstöm; Gunilla Enblad; Claes Mercke; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hsp90; EGFR; LRIG; microtubule; telomerase; oesophageal cancer; imetelstat; DNA double-strand break; 17-AAG; radiation; prognosis; radiosensitisation; microtubule targeting agents; Oncology; Onkologi; Oncology; Onkologi;

   Sammanfattning : Oesophageal cancer is a malignant and aggressive disease with very poor survival. The aim of this thesis was to evaluate novel therapeutic targets in oesophageal cancer. In paper I, Hsp90 was expressed in all 81 oesophageal cancer tissues and also in nine oesophageal cancer cell lines. LÄS MER