Sökning: "CD8 TILs"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden CD8 TILs.

1. 1. The use of immunological biomarkers to improve individualization of postoperative radiotherapy in breast cancer

   Författare :Axel Stenmark Tullberg; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tumor-infiltrating lymphocytes; CD8; FOXP3; Radiotherapy; Breast cancer;

   Sammanfattning : Radiotherapy (RT) forms the cornerstone of most curative breast cancer treatment due to its well-established risk-reducing effect on local recurrences at the population level. However, there is heterogeneity regarding treatment benefits at the individual level, and research currently aims to better tailor treatment decisions based on tumor biology. LÄS MER

3. 2. Leucine-rich repeats and immunoglobulin-like domain (LRIG) proteins : possible prognostic markers in vulvar squamous cell carcinoma, endometrial carcinoma, and oropharymgeal squamous cell carcinoma

   Författare :Husam Oda; David Lindquist; Eva Lundin; Ulrika Ottander; Kristina Stefansson; Kate Cuschieri; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vulvar squamous cell carcinoma; endometrial carcinoma; oropharyngeal squamous cell carcinoma; LRIG1-3; HPV; LMO7; HPV-driven; non-HPV-driven; prognosis; overall survival; disease-free survival; p53; Ki-67; CD8 TILs; CD44.; Pathology; patologi;

   Sammanfattning : The human leucine-rich repeats and immunoglobulin-like domain (LRIG) gene family comprises three genes, LRIG1, LRIG2 and LRIG3, which encode the LRIG1, LRIG2 and LRIG3 proteins, respectively. Previous stidies have revealed the different prognostic roles of these proteins in different cancers, and it has been shown that LRIG1 functions as a tumour suppressor in certain cancers via its negative regulation of several receptor tyrosine kinases. LÄS MER

4. 3. HPV and potential prognostic markers in primary vaginal carcinoma

   Författare :Cecilia Ranhem; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The overall aim of this PhD thesis is to evaluate HPV status and immunohistochemical expression of different biomarkers, including tumor suppressor p16, proliferation marker Ki67, molecular markers in the LRIG family, WRAP53ß, and dyskerin as well as immune markers CD4+ and CD8+ TILs, and their correlation to clinical manifestations and survival as part of a search for potential prognostic factors in women diagnosed with primary vaginal cancer. Paper I evaluates the presence of HPV in vaginal cancer tumor samples, as well as immunohistochemical expression of p16 and Ki-67. LÄS MER

5. 4. Immune Cell Profiling of Colorectal Cancers: Unravelling the Connection to Treatment Responses

   Författare :Azar Rezapour; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rectal cancer; Tumor infiltrating T cell; MxA; Interferon type I; CD39; CD103; PD-1; cytokines; response to the treatment;

   Sammanfattning : Understanding the interplay between tumor cells and the immune system holds the key to the development of more effective treatments for cancer patients. Therefore, we have emphasized our efforts on deciphering the intricacies of these interactions to pave for more effective therapeutic strategies. LÄS MER

7. 5. Hunting the end of the rainbow : prognostic biomarkers and human papillomavirus in tonsillar and base of tongue cancer

   Författare :Nikolaos Tertipis; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Aim: The aim of this thesis was to hunt for additional prognostic biomarkers in HPV positive TSCC and BOTSCC to identify patients that could if they wished, be enrolled in clinical trials for de-escalation of treatment. Background. LÄS MER