Sökning: "Intermediate"

Visar resultat 11 - 15 av 1560 avhandlingar innehållade ordet Intermediate.

  1. 11. Electrochemical and Enzymatic In Vitro Studies on Reactive Drug Metabolites. Synthesis, Characterization and Avoidance

    Författare :Tove Johansson Mali´n; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cytochrome P450; Drug; Electrochemical oxidation; Electrochemistry; Intermediate; Metabolism; Metabolic activation; Mimicry; Reactive Metabolite; Trapping.;

    Sammanfattning : During development of pharmaceuticals, it is essential to as early as possible identify and preferably avoid formation of reactive metabolites and intermediates. Reactive metabolites may represent obstacles in the development and use of drugs, due to their potential toxicity. LÄS MER

  3. 12. Hardware-Aware Algorithm Designs for Efficient Parallel and Distributed Processing

    Författare :Charalampos Stylianopoulos; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; resource-constrained; distributed processing; high-end; parallelism; hardware-aware; intermediate;

    Sammanfattning : The introduction and widespread adoption of the Internet of Things, together with emerging new industrial applications, bring new requirements in data processing. Specifically, the need for timely processing of data that arrives at high rates creates a challenge for the traditional cloud computing paradigm, where data collected at various sources is sent to the cloud for processing. LÄS MER

  4. 13. Modelling of molybdopterin-dependent enzymes

    Författare :Anders Thapper; Kemiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Inorganic chemistry; enzymes; transition state; intermediate; mechanism; molybdopterin; density functional theory; model systems; oxygen atom transfer; molybdenum; tungsten; Oorganisk kemi; Chemistry; Kemi;

    Sammanfattning : The thesis deals with models for molybdopterin-dependent enzymes. Several model systems containing molybdenum or tungsten have been prepared and characterised, and their reactivity with oxygen atom acceptors and donors have been investigated. LÄS MER

  5. 14. The Folding Energy Landscape of MerP

    Författare :Ann-Christin Brorsson; Bengt-Harald Jonsson; Daniel Otzen; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; protein folding and stability; hydrogen exchange; intermediate; partial unfolding; Biokemi; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : This thesis is based on studies, described in four papers, in which the folding energy landscape of MerP was investigated by various techniques. MerP is a water-soluble 72 amino acid protein with a secondary structure consisting of four anti-parallel β-strands and two α-helices on one side of the sheet in the order β1α1β2β3α2β4. LÄS MER

  7. 15. Leveraging Intermediate Representations for High-Performance Portable Discrete Fourier Transform Frameworks : with Application to Molecular Dynamics

    Författare :Måns Andersson; Stefano Markidis; Artur Podobas; Niclas Jansson; Ivy Bo Peng; Hartwig Anzt; KTH; []
    Nyckelord :Intermediate Representation; Discrete Fourier Transform; Fast Fourier Transform; Molecular Dynamics; Mellankod; diskret Fouriertransform; snabb Fouriertransform; Molekyldynamik;

    Sammanfattning : The Discrete Fourier Transform (DFT) and its improved formulations, the Fast Fourier Transforms (FFTs), are vital for scientists and engineers in a range of domains from signal processing to the solution of partial differential equations.  A growing trend in Scientific Computing is heterogeneous computing, where accelerators are used instead or together with CPUs. LÄS MER