Sökning: "Human pluripotent stem cells"

Visar resultat 26 - 30 av 100 avhandlingar innehållade orden Human pluripotent stem cells.

  1. 26. Building the Bridge from Bench to Bedside: Ethical Issues in Translational Stem Cell Research

    Författare :Kristina Hug; Medicinsk etik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Translational stem cell research; research ethics; values; experimental stem cell-based therapies; patient safety; treatment efficacy; treatment accessibility; first-in-human trials; Parkinson’s disease; Huntington’s disease; priority setting; right to withdraw; human biological material; informed consent;

    Sammanfattning : Abstract in UndeterminedTranslational stem cell research raises many interesting ethical questions, which have, to a greater or lesser degree, been debated at an international as well as at an interdisciplinary level. Nevertheless, there is still no international consensus regarding how a number of ethical questions related to this research should be answered. LÄS MER

  3. 27. Exploring the dynamic epigenome in pluripotent stem cells using quantitative methods

    Författare :Angelo Salazar Mantero; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A totipotent stem cell has the potential to give rise to the trillions of cells in the human body, all carrying the very same genetic information. Through differentiation events, gene expression changes guided by epigenetic mechanisms resulting in specialized phenotypes. LÄS MER

  4. 28. Derivation, enrichment and characterization of dopaminergic neurons from pluripotent stem cells

    Författare :Catherine Michele Schwartz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson s disease (PD) is characterized by progressive degeneration of dopaminergic (DA) neurons residing in the substantia nigra and innervating the straitum. Current medical interventions provide initial symptomatic relief, but unfortunately do not slow or reversing the disease course. LÄS MER

  5. 29. Transposable Elements in Neural Progenitor Cells

    Författare :Liana Fasching; Molekylär neurogenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transposable Elements; TRIM28; Epigenetic Regulation; Gene Expression; Neural Progenitor Cells;

    Sammanfattning : More than 90% of DNA does not code for proteins and for a long time these sequences were referred to as “junk DNA” due to their unknown purpose. With the advent of new technologies it is now known, that the non-coding part of the genome is of great importance for regulating gene expression and is therefore indispensable. LÄS MER

  7. 30. The Effects of Genetic and Epigenetic Variation on Human Pluripotent Stem Cell Differentiation

    Författare :Roksana Moraghebi; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Human pluripotent stem cells (PSCs) are widely used for studying embryonic development, disease modelling, drug discovery and cell therapy development. Using human PSCs as a model has significantly contributed to our understanding of embryonic development and elucidating novel pathological mechanisms as well as developing new drugs. LÄS MER