Sökning: "Human pluripotent stem cells"
Visar resultat 21 - 25 av 100 avhandlingar innehållade orden Human pluripotent stem cells.
21. Genetic modification and mesodermal differentiation of human embryonic stem cells
Sammanfattning : Background: Pluripotent human embryonic stem cells (hESCs) are a resource of great potential, available for research. Their capability to differentiate into any cell of the human body and an unlimited in vitro expansion offers the possibility to study the earliest human development and provides a source of cells for regenerative medicine. LÄS MER
22. Magnetic bead-based isolation of biological therapeutic modalities
Sammanfattning : Biopharmaceutical modalities, such as monoclonal antibodies or the less established cell therapies, are nowadays very important for the treatment of severe or incurable diseases. The manufacturing of such modalities is complex and costly, including the downstream processing, which is highly essential to ensure the safety and quality of the product. LÄS MER
23. Stem cell-based models to study cellular alterations in Parkinson’s Disease
Sammanfattning : Parkinson’s Disease (PD) is the most prevalent neurodegenerative movement disorder. Despite investigative efforts into the pathogenesis of the disease, the aetiology and mechanism of PD remains unknown, with multiple factors and cellular pathways known to play a part. LÄS MER
24. Induced pluripotent stem cell (iPSC) modelling for the identification of mechanisms behind neurodevelopmental disorders
Sammanfattning : Human induced pluripotent stem cells (iPSCs) have opened new possibilities to recapitulate disease mechanisms and to model disorders in vitro. In the studies presented here, iPSCs were established to model neural differentiation in Down syndrome (DS), caused by trisomy for chromosome 21 (T21); Dravet syndrome (DRS), caused by variants in the SCN1A gene; and an ataxia syndrome, caused by a variant in the NFASC gene. LÄS MER
25. Specification and potency of human neural stem cells for clinical transplantation
Sammanfattning : Neural stem cells hold promise for future treatment of spinal cord injury. Various aspects regarding cell fate specification, manufacturing and monitoring, with implications for clinical applications of these cells, are discussed herein. LÄS MER