Sökning: "Human pluripotent stem cells"

Visar resultat 11 - 15 av 100 avhandlingar innehållade orden Human pluripotent stem cells.

1. 11. Novel Culture Strategies and Signal Transduction Pathways of Pluripotent Stem Cells

   Författare :Sara Pijuan Galitó; Cecilia Annerén; Lena Kjellén; Christopher Ward; Uppsala universitet; []
   Nyckelord :Pluripotent stem cells; Inter-alpha inhibitor; culture method; Biologi med inriktning mot molekylär cellbiologi; Biology with specialization in Molecular Cell Biology; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Sammanfattning : Pluripotent stem cells (PSCs) can self-renew indefinitely in culture while maintaining their capacity to differentiate into any cell type of an organism, thus offering novel sources for drug screening, in vitro disease modelling, and cell replacement therapies. However, due to their sensitive nature, many PSC lines are still cultured using undefined components such as serum or serum-derived components, on either feeder cells or complex protein mixes such as Matrigel or gelatine. LÄS MER

3. 12. Human pluripotent stem cells : effects of handling and microenvironment

   Författare :Frida Holm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Pluripotent stem cells hold great promise in regenerative medicine and drug development due to their developmental potential towards multiple lineages. However, there are still hurdles to overcome before these cells are safe enough for clinical use even though attempts have already been initiated. LÄS MER

4. 13. Transcriptional profiling of human embryonic stem cells and their functional derivatives

   Författare :Jane Synnergren; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; transcription; differentiation; human embryonic stem cells; gene expression; Naturvetenskap;

   Sammanfattning : Human embryonic stem cells (hESCs) represent populations of pluripotent, undifferentiated cells with unlimited replication capacity, and with the ability to differentiate into any functional cell type in the human body. Based on these properties, hESCs and their derivatives provide unique model systems for basic research on embryonic development. LÄS MER

5. 14. Derivation, Characterization and Differentiation of Feeder-Free Human Embryonic Stem Cells

   Författare :Narmin Bigdeli; Göteborgs universitet; []
   Nyckelord :Embryonic Stem Cells; Differentiation;

   Sammanfattning : Human embryonic stem cells (hESCs) are pluripotent cells with self-renewal ability, derived from the inner cell mass of a human blastocyst. They have the remarkable potential to develop into different cell types and can thus be used to regenerate and restore damaged tissues and organs in the entire body. LÄS MER

7. 15. Modeling human germ cell development with pluripotent stem cells and characterizing the putative oogonial stem cells

   Författare :Sarita Panula; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The current understanding of human germ cell development is limited and is at most parts extrapolated from studies of mice or other model organisms. Particularly, the specification events of human germ cell lineage are largely unknown, which is at least in part due to inaccessibility of early stages of human development. LÄS MER