Sökning: "High-grade glioma"

Visar resultat 6 - 10 av 27 avhandlingar innehållade orden High-grade glioma.

1. 6. Towards Novel Biomarkers for Low-grade Glioma

   Författare :Shala Ghaderi Berntsson; Anja Smits; Peter Siesjö; Uppsala universitet; []
   Nyckelord :Low-grade glioma; prognosis; epilepsy; PROX1; DNA repair enzyme; PET; Physiological MRI; Neuroscience; Neurovetenskap;

   Sammanfattning : Gliomas are common primary brain tumours that occur as low-grade (LGG) and high-grade gliomas (HGG). Typically occurring in younger adults, LGG has an indolent course with a median survival of 5-10 years, but carries an inherent potential for transforming into HGG. LÄS MER

3. 7. Stem cell signatures in glioma

   Författare :Xiaobing He; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Gliomas are the most common tumors of the central nervous system in adults. Glioblastoma, the most aggressive form, has a median survival of 15 months regardless of the standard treatment with surgery and temozolomide-based radiochemotherapy. Therefore, it is imperative to improve treatment options for patients with glioblastoma. LÄS MER

4. 8. Deciphering microglia plasticity in glioma

   Författare :Dalel Saidi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Microglia are the innate immune cells of the brain. One of the main characteristics of microglia is its extremely plasticity, which is necessary for them to deal with changing circumstances. Activation of microglia can contribute to contrasting effects by either proinflammatory, anti-inflammatory, or tumor-supportive phenotypes. LÄS MER

5. 9. Tertiary lymphoid structures in glioblastoma : Discovery, Characterization and Therapeutic Induction

   Författare :Alessandra Vaccaro; Anna Dimberg; Victor Engelhard; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tertiary lymphoid structures; Glioma; Glioblastoma; Immunotherapy; Immunologi; Immunology; Oncology; Onkologi;

   Sammanfattning : Glioblastoma (GBM) is an incurable brain cancer with a median survival of less than two years from diagnosis. The tumor microenvironment plays a major role in GBM progression through sustaining immunosuppression and poor lymphocytic infiltration. LÄS MER

7. 10. Molecular Regulation of Inflammation and Angiogenesis in the Tumor Microenvironment

   Författare :Lothar Dieterich; Anna Dimberg; Lena Claesson-Welsh; Jonas Fuxe; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; stroma; glioma; alphaB-crystallin; HSPB5; cryab; myeloid cells; Morphology; cell biology; pathology; Morfologi; cellbiologi; patologi; Cell and molecular biology; Cell- och molekylärbiologi; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Tumor growth and progression not only depend on properties of the malignant cells but are strongly influenced by the tumor microenvironment. The tumor stroma consists of various cell types such as inflammatory cells, endothelial cells and fibroblasts, which can either inhibit or promote tumor growth. LÄS MER