Avancerad sökning

Visar resultat 1 - 5 av 27 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Prognostic Biomarkers and Target Proteins for Treatment of High-grade Gliomas

    Författare :Linda Sooman; Simon Ekman; Johan Lennartsson; Joachim Gullbo; Michael Bergqvist; Erik Blomquist; Stefan Bergström; Beatrice Melin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; High-grade glioma; prognostic biomarkers; combination chemotherapy; DNA methylation; FGF2; p38 MAPK; PTPN6; camptothecin; imatinib; vandetanib; EGFR; RAC1; Notch; Medical Science; Medicinsk vetenskap; Oncology; Onkologi;

    Sammanfattning : The survival for high-grade glioma patients is poor and the treatment may cause severe side effects. A common obstacle in the treatment is chemoresistance. To improve the quality of life and prolong survival for these patients prognostic biomarkers and new approaches for chemotherapy are needed. LÄS MER

  3. 2. Modeling and investigations of high-grade glioma to understand tumorigenesis and heterogeneity

    Författare :Nagaprathyusha Maturi; Lene Uhrbom; Helena Carén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioblastoma; diffuse pediatric-type high-grade glioma; cell of origin; heterogeneity; serum culture; glioblastoma stem cell; chromatin accessibility; cross-species conservation; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : Glioblastoma (GBM) is the most common primary malignant brain tumor. As per 2021 WHO classification, the corresponding diagnosis in children is called diffuse pediatric-type high-grade glioma (pHGG). In both cases tumors are histone 3 (H3) and isocitrate dehydrogenase 1/2 (IDH1/2) wildtype (wt). LÄS MER

  4. 3. Cell-based models for studying paediatric high-grade gliomas

    Författare :Susanna Larsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; paediatric brain tumour; glioblastoma; glioma stem cell; primary culture; xenograft tumour; zebrafish;

    Sammanfattning : Brain tumours are the largest group of solid tumours in children and accounts for most cancer-related deaths. Astrocytoma is the largest group, representing almost half of the brain tumours, where high-grade glioma is one of the most devastating forms with very poor prognosis due to lack of efficient treatments. LÄS MER

  5. 4. Molecular Regulation of Vascular Abnormalization and Its Role in Glioma

    Författare :Lei Zhang; Anna Dimberg; Rolf Bjerkvig; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; vasculature; pleiotrophin; PTN; CD93; angiogenesis; GL261; RCAS;

    Sammanfattning : Glioblastoma, grade IV glioma, is the one of the deadliest cancers, with a median survival of only 12-15 months despite aggressive treatment including surgery, chemotherapy and radiation. One hallmark of glioblastoma is the morphological and functional abnormalization of tumor blood vessels. LÄS MER

  7. 5. A Novel Approach for Radiotherapy and Radiosurgery Treatment Planning Accounting for High-Grade Glioma Invasiveness into Normal Tissue

    Författare :Wille Häger; Iuliana Toma-Daşu; Marta Lazzeroni; Jesper Kallehauge; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Tumor modeling; medical physics; model; simulation; glioblastoma; gbm; medicinsk strålningsfysik; Medical Radiation Physics;

    Sammanfattning : High-grade gliomas (HGGs) are a type of malignant brain cancer, which include glioblastomas (GBMs). In adults, GBM is the most common malignant primary brain cancer. Attempts to treat patients with GBMs have been conducted for over a century, but the prognosis has only marginally improved. LÄS MER