Sökning: "Y-1 cells"

Hittade 5 avhandlingar innehållade orden Y-1 cells.

  1. 1. In Vitro Studies of Adrenocorticolytic DDT Metabolites, with Special Focus on 3-methylsulfonyl-DDE

    Författare :Vendela Asp; Ingvar Brandt; Ulrika Bergström; Olle Söder; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicity; 3-methylsulfonyl-DDE; CYP; adrenal cortex; metabolic activation; steroid hormones; Y-1; H295R; mitotane; adrenocortical carcinoma; Toxicology; Toxikologi; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Sammanfattning : The DDT metabolite 3-methylsulfonyl-DDE (3-MeSO2-DDE) is bioactivated by cytochrome P450 11B1 (CYP11B1) in the adrenal cortex of mice and forms irreversibly bound protein adducts, reduces glucocorticoid secretion, and induces cell death selectively in cortisol-producing adrenocortical cells. 3-MeSO2-DDE has therefore been proposed as a lead compound for an improved adrenocortical carcinoma (ACC) therapy. LÄS MER

  3. 2. Adrenocorticolysis Induced by 3-MeSO2-DDE : Mechanisms of Action, Kinetics and Species Differences

    Författare :Veronica Lindström; Ingvar Brandt; Ulrika Bergström; Eva Brittebo; Hans Tjälve; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Toxicology; 3-methylsulphonyl-DDE; o; p -DDD; CYP11B1; adrenal cortex; tissue-specific toxicity; bioactivation; kinetics; Y-1 cells; Toxikologi; Biology; Biologi;

    Sammanfattning : The DDT metabolite 3-methylsulphonyl-DDE (3-MeSO2-DDE) induces cell death specifically in the adrenal cortex of mice after a cytochrome P45011B1 (CYP11B1)-catalysed bioactivation. This substance is not only an environmental pollutant, but also a suggested lead compound for an improved chemotherapy of adrenocortical carcinoma (ACC). LÄS MER

  4. 3. Regulation of germline transcription in the immunoglobulin heavy chain locus

    Författare :Jurga Laurencikiene; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During an immune response, activated B cells develop into high rate immunoglobulin (Ig) secreting plasma cells. They also switch from production of IgM to IgG, IgA or IgE. Specific isotypes of antibodies have functional and structural features that make them particularly well suited to defend against different types of pathogens. LÄS MER

  5. 4. From the Electronic Structure of Point Defects to Functional Properties of Metals and Ceramics

    Författare :David Andersson; Börje Johansson; Pavel Korzhavyi; Benjamin Burton; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; first principles; ab initio; density functional theory; Calphad; point defects; diffusion; solid electrolytes; oxygen storage materials; Material physics with surface physics; Materialfysik med ytfysik;

    Sammanfattning : Point defects are an inherent part of crystalline materials and they influence important physical and chemical properties, such as diffusion, hardness, catalytic activity and phase stability. Increased understanding of point defects enables us to tailor the defect-related properties to the application at hand. LÄS MER

  7. 5. Basal lamina genes affected in leiomyomatosis and congenital muscular dystrophy : structure and mutation analyses of the collagen COL4A6 and laminin LAMA2 genes

    Författare :Xu Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Basal laminae (basement membranes) are flexible thin sheets of specialized extracellular matrix separating organ cells from the underlying or surrounding connective tissues. They are found beneath epithelial and endothelial cells amd surrounding different cells, such as muscle fibers and nerves. LÄS MER