Sökning: "Acetylcholine synthesis"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden Acetylcholine synthesis.

  1. 1. On The Innervation of Salivary Glands and Treatment of Dry Mouth - An Experimental and Clinical Study

    Författare :Nina Khosravani; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parotid gland; Denervation; Acetylcholine synthesis; Otic ganglion; Auriculo-temporal nerve; Facial nerve; Neuropeptides; Salivary gland hypofunction; Physostigmine;

    Sammanfattning : Detailed knowledge of the innervation of the parotid gland is essential in basic studies on various neuroglandular phenomena as well as in various types of orofacial surgery. The innervation is more complex than usually depicted in Textbooks. LÄS MER

  2. 2. Molecular Mechanisms of Reward and Aversion

    Författare :Anna Klawonn; David Engblom; Anders Blomqvist; Paul Kenny; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Motivation; Dopamine; Reward; Aversion; Negative affect; Systemic Inflammation; Drug Addiction; Cytokines; Prostaglandin E2; Melanocortin receptor 4; Acetylcholine; Muscarinic M4 receptor;

    Sammanfattning : Various molecular pathways in the brain shape our understanding of good and bad, as well as our motivation to seek and avoid such stimuli. This work evolves around how systemic inflammation causes aversion; and why general unpleasant states such as sickness, stress, pain and nausea are encoded by our brain as undesirable; and contrary to these questions, how drugs of abuse can subjugate the motivational neurocircuitry of the brain. LÄS MER

  3. 3. Exploring Palladium-Mediated 11C/12C-Carbonylation Reactions : PET Tracer Development Targeting the Vesicular Acetylcholine Transporter

    Författare :Sara Roslin; Mats Larhed; Gunnar Antoni; Jonas Eriksson; Luke Odell; Victor Pike; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Carbonylation; palladium; carbon-11; radiochemistry; positron emission tomography; vesicular acetylcholine transporter; vesamicol; alkyl halide; oxidative carbonylation; acylamidine; oxadiazole; heterocycle; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The work presented herein describes the utilization and exploration of palladium-mediated incorporations of carbon monoxide and/or [11C]carbon monoxide into compounds and structural motifs with biological relevance.The first part of the thesis describes the design, synthesis and 11C-labeling of prospective PET tracers for the vesicular acetylcholine transporter (VAChT), a target affected in several neurodegenerative diseases. LÄS MER

  4. 4. Targeting Biological Systems by Organic Synthesis Methods - Cancer Cells and Proteins

    Författare :Cecilia Winander; Lars Baltzer; Stefan Sjöberg; Jörgen Carlsson; Vladimir Tolmachev; Thomas Schrader; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; carborane; doxorubicin; 125I; molecular recognition; four-helix bundle; polypeptide conjugate; affinity; chitinase; acetylcholine esterase; Organisk kemi;

    Sammanfattning : This thesis describes the design and synthesis of molecules with potential roles in biomedicine, with an emphasis on molecular recognition in complex biological environments. The first chapter describes the synthesis and evaluation of compounds for use in nuclide therapy. LÄS MER

  5. 5. On the synthesis, release and function of acetylcholine in the central nervous system

    Författare :Sten-Magnus Aquilonius; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER