Sökning: "H ATPase"

Visar resultat 21 - 25 av 47 avhandlingar innehållade orden H ATPase.

  1. 21. The mitochondrial adenosine triphosphatase complex : studies on the interaction between its catalytic and H⁺-translocation components

    Författare :Elzbieta Glaser; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The aim of the present investigation was the characterization of the mitochondrial adenosine triphosphatase complex, with respect to its subunit composition and to the function of the individual components in the interaction between the catalytic and H+-translocating processes catalysed by this enzyme.The enzyme consists of two structurally and morphologically different units: a hydrophilic part Fl, the centre for the catalysis of the hydrolysis and synthesis of ATP, and a membrane part Fo, which constitutes a binding site for Fl and mediates the translocation of protons through the membrane. LÄS MER

  3. 22. Repurposing digitoxin in the treatment of pancreatic ductal adenocarcinoma : genotypic and phenotypic features as biomarkers for digitoxin sensitivity in vitro

    Författare :Heléne Lindholm; Katarina Ejeskär; Ferenc Szekeres; Maria Faresjö; Sofie Mohlin; Högskolan i Skövde; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic ductal adenocarcinoma; Na K -ATPase; digitoxin; cardiac glycoside; metabolomics; choline; Translationell medicin TRIM; Translational Medicine TRIM;

    Sammanfattning : The incidence of pancreatic ductal adenocarcinoma (PDAC) is increasing worldwide. The dismal prognosis and lack of effective treatments urges for increased research efforts in developing new treatment regimens. Since the development of new cancer treatments are expensive and time consuming, repurposing drugs is preferable when possible. LÄS MER

  4. 23. Manipulation of potassium ion fluxes to induce apoptosis in lung cancer cells

    Författare :Britta Andersson; Kjell Grankvist; Parviz Behnam-Motlagh; Roger Henriksson; Ola Brodin; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apoptosis; Cisplatin; Intracellular K content; Mesothelioma; Na K ATPase pump; Clinical chemistry; Klinisk kemi;

    Sammanfattning : Apoptosis is a special form of cell death that if non-functional may lead to diseases such as cancer. A reduction of the intracellular potassium ion (K+) content is necessary for activating enzymes important for the execution of apoptosis. LÄS MER

  5. 24. The role of catecholamines in regulation of renal tubular sodium transport

    Författare :Ulla Holtbäck; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :sodium balance; Na ; H -antiporter; Na ; K -ATPase; renal proximaltubules; hormonal regulation.;

    Sammanfattning : Renal sodium metabolism, a major determinant of arterial blood pressure, is regulated with remarkable precision by a variety of endocrine, autocrine and neuronal factors. All these factors are known to regulate sodium metabolism by affecting the rate of renal tubular sodium reabsorption. LÄS MER

  7. 25. Regulation of ion transport in the gastrointestinal tract : aspects of early development

    Författare :Lena Grahnquist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Gastrointestinal transport; early development; ontogeny; ion; sodium; potassium; H ; K -ATPase; Na - K - 2Cl- cotransporter; barium-sensitive potassium channels; Na ; K -; ATPase; dopamine; angiotensin II; glucocorticoids; rat; human;

    Sammanfattning : Ion transport in the gastrointestinal tract is vital for cellular homeostasis and to ensure growth during ontogeny. We have therefore investigated the regulation and maturation of sodium, potassium and hydrogen transport in the gastrointestinal tract. Net jejunal sodium absorption is significantly higher in young as compared to adult rats. LÄS MER