Sökning: "G1 phase"

Visar resultat 1 - 5 av 84 avhandlingar innehållade orden G1 phase.

  1. 1. G1-phase cyclin expression in neoplastic B cells

    Författare :Richard Scuderi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cell cycle; G1 phase; cyclin D; cyclin E; EBV; Burkitt s; B-ALL; B-CLL; apoptosis;

    Sammanfattning : By virtue of the role of G1-phase cyclin proteins as regulators of differentiation, proliferation, and apoptosis, their improper expression can lead to altered cellular homeostasis and tumor formation. Cyclins provide the regulatory partner for cyclin-cdk complexes whose enzymatic activity drives cell cycle progression. LÄS MER

  3. 2. Single cell analysis of checkpoints in G1

    Författare :Hanna-Stina Martinsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cell cycle; restriction point; cyclin D; pRb; rRNA synthesis; cell growth; attachment;

    Sammanfattning : It is becoming evident that defective cell cycle regulation is an important property of the cancer cell. The restriction point (R), a G1 checkpoint after which cell cycle progression becomes independent of extracellular growth factors, is often aberrant in cancer cells. LÄS MER

  4. 3. Statistical Modelling of Cell Cycle Dynamics Analysis and Interpretation of BrdUrd DNA FCM-Derived Data

    Författare :Sara Larsson Lönn; Matematisk statistik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; G2 phase duration; DNA replication; flow cytometry; Natural science; Naturvetenskap; S phase duration; DNA distribution; branching processes; cell cycle kinetics;

    Sammanfattning : It it of great importance to increase the knowledge of various cell cycle kinetic parameters and the objective of this thesis is to use stochastic models to interpret Bromodeoxyuridine (BrdUrd) DNA Flow Cytometry (FCM) derived data in order to estimate such parameters. The cell cycle is the process of growth and division that is essential for an organism to increase in size. LÄS MER

  5. 4. Studies on the antiproliferative action of interferon : effects on proteins synthesized in the G1 and S phase of the cell cycle in 2 anchorage-dependent cell lines

    Författare :Dan Lundblad; Erik Lundgren; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Interferon; Glioma; Antiproliferative effect; DNA polymerase; Thymidine kinase; 2 -5 oligo A; Protein synthesis; Two-dimensional electrophorensis; Mouse fibroblasts; C-myc; KI-67 antigen;

    Sammanfattning : Interferons (IFNs) are a class of structurally related proteins first discovered to be produced by virus-infected cells. By now, several other inducing agents have been described. LÄS MER

  7. 5. Polyamines are involved in the regulation of S phase and DNA synthesis

    Författare :Kersti Alm; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Djurfysiologi; Animal physiology; cell cycle regulation; p53; DNA strand breaks; replicon organization; topoisomerase II;

    Sammanfattning : Our research group has previously shown that treatment with the polyamine biosynthesis inhibitors a-difluoromethylornithine (DFMO) or amidinoindan-1-one 2´-amidinohydrazone (CGP 48664) inhibited S phase progression before any other cell cycle phase was affected. This study was undertaken to further investigate the role of polyamines in the regulation of S phase progression and DNA synthesis. LÄS MER