Sökning: "Burkitt s"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden Burkitt s.

  1. 1. In silico analysis of pathways targeted by EBV infection and malignant transformation

    Författare :Ramakrishna Rao Sompallae; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Bioinformatics; systems biology; gene expression analysis; Epstein-Barr virus; Burkitt s lymphoma;

    Sammanfattning : Epstein-Barr virus (EBV) is a ubiquitous γ-herpes virus with dual cell tropism for human B-lymphocytes and epithelial cells. EBV infection is linked to several malignancies such as Burkitt s lymphoma (BL) and nasopharyngeal carcinoma (NPC). LÄS MER

  3. 2. Functional characterization of the alternative reading frame protein p14ARF

    Författare :Mikael Lindström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :p14ARF; p19ARF; alternative reading frame; CDKN2A; p53; B23; nucleophosmin; Burkitt´s lymphoma; nucleolus; senescence; Myc; E2F; phosphorylation; RNA interference; ribosome biogenesis;

    Sammanfattning : A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears as a common theme in most malignant human tumors. LÄS MER

  4. 3. Identification and functional characterization of Epstein-Barr virus-encoded deconjugases

    Författare :Sebastian Hildebrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The post-translational conjugation or deconjugation of proteins by ubiquitin (Ub) or ubiquitin-like molecules (UbLs: e.g. SUMO, NEDD8, ISG15) has emerged as a major regulatory mechanism of various cellular activities. LÄS MER

  5. 4. Characterization of non-coding mRNA in Epstein-Barr virus

    Författare :Åsa Isaksson; Göteborgs universitet; []
    Nyckelord :Epstein-Barr virus; EBNA1; IRES; PTLD; alternative splice; nucleotide substitution; protein interactions;

    Sammanfattning : Epstein-Barr virus (EBV) is a human gammaherpesvirus that infects lymphoid and epithelial cells. The virus is the causative agent of infectious mononucleosis, a self-limiting lymphoproliferative disease, and it is additionally associated with various malignancies including Burkitt?s lymphoma, Hodgkin?s disease and lymphoproliferative syndromes in immunocompromised individuals. LÄS MER

  7. 5. Epstein-Barr virus encoded deconjugases and AmotL2 in control of cell topology

    Författare :Sebastian Hildebrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : EPSTEIN-BARR VIRUS ENCODED DECONJUGASES: The post-translational conjugation or deconjugation of proteins by ubiquitin (Ub) or ubiquitin-like molecules (UbLs: e.g. SUMO, NEDD8, ISG15) has emerged as a major regulatory mechanism of various cellular activities. Viruses have developed mechanisms to exploit those pathways for their own benefit. LÄS MER