Sökning: "ESR2"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet ESR2.

  1. 1. Breast Cancer Biomarkers with Clinical Relevance Identified by Massively-parallel DNA and RNA Sequencing

    Författare :Malin Dahlgren; Translational Oncogenomics; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; DNA sequencing; RNA sequencing; Metastasis; Biomarker; Estrogen receptor alpha; Estrogen receptor beta; ESR1; ESR2; Breast cancer; DNA sequencing; RNA sequencing; metastasis; biomarker; Estrogen receptor alpha; Estrogen receptor beta; ESR1; ESR2;

    Sammanfattning : Women have a 10% lifetime risk of developing breast cancer, and the disease has surpassed lung cancer as the most frequently diagnosed type of cancer in the world. Breast cancer originates in the epithelial cells of the mammary gland and tumor cells have undergone a series of genetic and phenotypic changes that confer tumor promoting properties. LÄS MER

  3. 2. Estrogen and its receptors in adipose tissue from women and men : Associations with age, adiposity and type 2 diabetes

    Författare :Fozia Ahmed; Jan Eriksson; Maria J. Pereira; Susanne Hetty; Karin Stenkula; Uppsala University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adipose tissue; estrogen; estrogen receptors; menopause; obesity; insulin resistance; type 2 diabetes.;

    Sammanfattning : Obesity and its complications, such as insulin resistance and type 2 diabetes (T2D), are leading causes of morbidity and mortality globally. Adipose tissue is important for whole-body homeostasis, functioning as an energy storage reservoir and an endocrine organ. LÄS MER

  4. 3. Hypospadias : analysis of a complex genetic disorder

    Författare :Ana Maria Beleza Meireles; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : BACKGROUND: Hypospadias is a common inborn error of the male urethra that involves an abnormally placed urethral opening. Its complex etiology is largely elusive to date. Twin and familial studies highlight a genetic background in hypospadias. Environmental factors have also been identified, particularly the exposure to endocrine disrupters. LÄS MER

  5. 4. Investigation of the genetic basis of familial non-BRCA1/2 breast cancer

    Författare :Paula Maguire; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Familial non-BRCA1 2 breast cancer; linkage analysis; CGH; association study;

    Sammanfattning : Breast cancer is the most common female malignancy in the Western world and approximately 510% of all breast cancer cases present with some degree of family history. In the mid-nineties genetic linkage analyses successfully identified two breast cancer predisposing genes, BRCA1 and BRCA2. LÄS MER

  7. 5. Male Subfertility and Prostate Cancer Risk: Epidemiological and Genetic Studies

    Författare :Yasir Ruhayel; Malmö Molekylärgenetisk reproduktionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytoplasmic and nuclear; Receptors; Prostatic neoplasms; genetic; Polymorphism; male; Infertility; Hypogonadism; Genetic association studies; Case–control studies; Androgens;

    Sammanfattning : Androgen action plays a pivotal role in male reproductive tract physiology and pathology. The androgen receptor (AR) gene harbors two codon repeat tracts: the CAG and GGN repeats, encoding corresponding amino acid sequences of variable length; the polyglutamine and polyglycine stretches, respectively. LÄS MER