Sökning: "ESR1"

Visar resultat 1 - 5 av 16 avhandlingar innehållade ordet ESR1.

  1. 1. Breast Cancer Biomarkers with Clinical Relevance Identified by Massively-parallel DNA and RNA Sequencing

    Författare :Malin Dahlgren; Translational Oncogenomics; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; DNA sequencing; RNA sequencing; Metastasis; Biomarker; Estrogen receptor alpha; Estrogen receptor beta; ESR1; ESR2; Breast cancer; DNA sequencing; RNA sequencing; metastasis; biomarker; Estrogen receptor alpha; Estrogen receptor beta; ESR1; ESR2;

    Sammanfattning : Women have a 10% lifetime risk of developing breast cancer, and the disease has surpassed lung cancer as the most frequently diagnosed type of cancer in the world. Breast cancer originates in the epithelial cells of the mammary gland and tumor cells have undergone a series of genetic and phenotypic changes that confer tumor promoting properties. LÄS MER

  3. 2. Systemic lupus erythematosus and rheumatoid arthritis : analyses of candidate genes involved in immune functions, for susceptibility and severity

    Författare :Martin Johansson; Solbritt Rantapää Dahlqvist; Ingrid Lundberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SLE; RA; oestrogen; renal disorder; ESR1; PDCD1; PTPN22; association; severity; Rheumatology; Reumatologi; Medicine; medicin;

    Sammanfattning : Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease with systemic manifestations characterized by auto-antibodies directed against different parts of the cell nucleus including DNA, histones and ribosomes. The systemic inflammation can cause damage to multiple organs, e.g., kidneys, skin, heart, lungs and the nervous system. LÄS MER

  4. 3. Analysis of Complex Genetic Traits in Population Cohorts using High-throughput Genotyping Technology

    Författare :Andreas Dahlgren; Ann-Christine Syvänen; Håkan Melhus; Markus Perola; Struan Grant; Uppsala universitet; []
    Nyckelord :Molecular medicine; SNP; TCF7L2; HHEX; COL11A1; ESR1; body height; type 2 diabetes mellitus; proinsulin; ULSAM; complex genetic trait; genotyping technology; Molekylärmedicin;

    Sammanfattning : Most human traits and common diseases have a complex genetic makeup involving more than one gene. The work presented in this thesis investigates standing body height and the common disease type 2 diabetes mellitus (T2DM). LÄS MER

  5. 4. Genetic susceptibility to breast and endometrial cancer

    Författare :Sara Wedrén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hormones are central in the carcinogenic process in the breast and in the uterine epithelium. Individual genetically determined variation in the response to hormonal influence may alter susceptibility to breast and endometrial cancers. Many small studies of this hypothesis have generated inconclusive results. LÄS MER

  7. 5. Zebrafish as a model to study the neuroendocrine system and toxicity of endocrine disruptors

    Författare :Gayathri Chandrasekar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Zebrafish is a popular vertebrate model system to study development and perform genetic analysis. It offers numerous advantages such as small size, short generation time, high fecundity, rapid and ex utero development of embryos and optically transparent embryos. LÄS MER