Sökning: "EPEC"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet EPEC.

  1. 1. Studies of the pathogenesis of Enterohemorrhagic Escherichia coli infections: pathogen virulence factors and host response

    Författare :Carla Calderon Toledo; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; host-pathogen; MyD88; TLRs; LEE; Shiga toxin; HUS; EHEC; EPEC; immune response; virulence factors;

    Sammanfattning : Enterohemorrhagic Escherichia coli (EHEC) is a highly virulent pathogen that can cause diarrhea and a life-threatening disease known as hemolytic uremic syndrome. EHEC possess an array of virulence factors that can exert severe consequences in the host. Shiga toxin constitutes a key virulence factor. LÄS MER

  3. 2. Passive immunisation as therapy for gastrointestinal infections in children

    Författare :Thomas Casswall; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Passive immunisation; treatment; bovine antibodies; chicken antibodies; rotavirus; Escherichia coli; ETEC; EPEC; Helicobacter pylori; clinical trials; infants; children;

    Sammanfattning : Several prophylactic studies in animals and humans have shown potential efficacy of oral therapy with non-human antibodies against different pathogens. Passive immunisation with oral antibodies against different pathogens is an attractive way to treat different gastrointestinal infections caused by pathogens such as rotavirus or enteropathogenic and enterotoxigenic Escherichia coli (EPEC; ETEC). LÄS MER

  4. 3. Citrobacter rodentium and Escherichia coli interactions with mucus producing colonic epithelical cells

    Författare :Sinan Sharba; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; A E pathogens; cytokines; epithelium; mitochondria; mucus;

    Sammanfattning : The epithelial cells together with the mucus layer protect the host from noxious luminal substances and pathogenic invasion. Pathogens have evolved numerous strategies to circumvent these barriers and mount infection. C. rodentium is a murine model for the attaching and effacing intestinal E. LÄS MER

  5. 4. Small Molecules as Tools in Biological Chemistry : Effects of Synthetic and Natural Products on the Type III Secretion System

    Författare :Caroline E. Zetterström; Mikael Elofsson; Samuel I. Miller; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Type III secretion; salicylidene acylhydrazide; virulence-blocker; virulence; inhibitor; target identification; neohopeaphenol A; Yersinia pseudotuberculosis; Pseudomonas aeruginosa; Escherichia coli; biologisk kemi; biological chemistry;

    Sammanfattning : The increasing use of antibiotics has led to a huge problem for society, as some bacteria have developed resistance towards many of the antibiotics currently available. To help find solutions to this problem we studied small molecules that inhibit bacterial virulence, the ability to cause disease. LÄS MER

  7. 5. Molecular and phenotypic characterization of diarrhoeagenic Escherichia coli from Nicaraguan children

    Författare :Bayardo Samuel Vilchez Rugama; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Diarrhoeal diseases continue to be a foremost public health problem worldwide, with over 1.5 million deaths occurring each year, mostly in children in developing countries. In Nicaragua, the mortality due to diarrhoea in children less than 5 years of age is 11 per 10,000 inhabitants. LÄS MER