Sökning: "DNA fragmentation"

Visar resultat 16 - 20 av 75 avhandlingar innehållade orden DNA fragmentation.

  1. 16. DNA checkpoint override and redox signaling in Schizosaccharomyces pombe

    Författare :Johanna J Sjölander; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Caffeine; Cell cycle; Checkpoint; Cdc25; Wee1; TORC1; FHIT; Proliferation; Aph1; Redox; Hypoxia; H2O2; Cysteine; Thiol; Allosteric; MAPK; Sty1; MAPKK; Wis1;

    Sammanfattning : This thesis covers intracellular stress signaling through genotoxic stress, overriding of checkpoint control, as well as cellular redox status in hypoxic and oxidative stress Papers I and II: Caffeine has been shown to override cell cycle checkpoints in humans as well as in the fission yeast Schizosaccharomyces pombe. Understanding of the mechanism may aid in the development of compounds with similar overriding mechanisms for sensitization in cancer therapy. LÄS MER

  3. 17. Population size and genetic diversity of Nigerian lions (Panthera leo)

    Författare :Talatu Tende; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; non-invasive sampling; faecal DNA; protected area; isolated population; Panthera leo;

    Sammanfattning : High growth rate in human populations, agricultural developments and industrialization have impinged negatively on the natural habitats of most large carnivores, causing fragmentation, isolation and consequently reduction in population size. Lions (Panthera leo) that once roamed most parts of Southern Europe, Asia, the Middle East, North America, northern part of South America and most parts of Africa are today found only in parts of sub-Saharan Africa and at a single site in India. LÄS MER

  4. 18. Genetic organization of encapsulated and non-encapsulated Haemophilus influenzae strains. Analysis of the glpTQ and 23S rRNA operons

    Författare :Xin-Ming Song; Malmö Klinisk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; intervening sequence; 23S rRNA; transcription; DNA sequence; glpT; Haemophilus influenzae; glpQ; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : Encapsulated Haemophilus influenzae type b (Hib) and non-encapsulated H. influenzae (NTHi) are important pathogens causing invasive and mucosal infections in children. A 42 kDa surface-exposed lipoprotein, protein D, has been found to be a potential virulence factor of NTHi. LÄS MER

  5. 19. Population Genetic Analyses of Natal Dispersal and Substructure in Three Bird Species

    Författare :Tobias Sahlman; Jan Ekman; Jacob Höglund; Ben J. Hatchwell; Uppsala universitet; []
    Nyckelord :Ecology; Perisoreus infaustus; Gallinago media; Lagopus muta; relatedness; philopatry; biased dispersal; phylogeography; microsatellite; mitochondrial DNA; Ekologi;

    Sammanfattning : Genetic variation within and among populations is a result of past and ongoing processes. Among the most important of such processes are dispersal, habitat fragmentation and selection. This thesis use neutral genetic variation as a tool to investigate these processes in three bird species. LÄS MER

  7. 20. On the mechanisms and consequences of cell to cell DNA transfer

    Författare :Jacob Ehnfors; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Development of cancer is a multistep process where an accumulation of genetic alterations drives normal cells to malignancy. In most cancer cells genetic changes can be observed both at the level of point mutations and as gains and losses of chromosomes. LÄS MER