Sökning: "Cdc25"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet Cdc25.

1. 1. DNA checkpoint override and redox signaling in Schizosaccharomyces pombe

   Författare :Johanna J Sjölander; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Caffeine; Cell cycle; Checkpoint; Cdc25; Wee1; TORC1; FHIT; Proliferation; Aph1; Redox; Hypoxia; H2O2; Cysteine; Thiol; Allosteric; MAPK; Sty1; MAPKK; Wis1;

   Sammanfattning : This thesis covers intracellular stress signaling through genotoxic stress, overriding of checkpoint control, as well as cellular redox status in hypoxic and oxidative stress Papers I and II: Caffeine has been shown to override cell cycle checkpoints in humans as well as in the fission yeast Schizosaccharomyces pombe. Understanding of the mechanism may aid in the development of compounds with similar overriding mechanisms for sensitization in cancer therapy. LÄS MER

3. 2. The ABC of the cell cycle : roles of the mammalian Cdc25 isoforms

   Författare :Andreas Lundgren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cell cycle progression is mediated by Cyclin dependent kinases (Cdks) in complex with Cyclins. The activity of the Cyclin-Cdk complexes is regulated through a variety of levels: expression and proteolysis of Cyclins, binding of inhibitors, phosphorylations and subcellular localization. LÄS MER

4. 3. Regulation of CDK dephosphorylation in mitotic entry

   Författare :Arne Lindqvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cell cycle progression is orchestrated by the activity of a Cyclin dependent kinase (Cdk) in complex with a Cyclin. The key regulator of early mitotic events is the Cyclin B1/Cdk1 complex. In G2, Cyclin B1/Cdk1 is kept inactive by phosphorylation in the active site of Cdk1. LÄS MER

5. 4. Computer Simulation of Protein Tyrosine Phosphatase Reaction Mechanisms and Dihydrofolate Reductase Inhibition

   Författare :Karin Kolmodin; Ernst-Walter Knapp; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molecular Biotechnology; Molekylär bioteknik;

   Sammanfattning : Protein tyrosine phosphatases catalyse the hydrolysis of phosphotyrosine residues in proteins, which is an important reaction in the cell signalling system. The three dimensional structure of such a protein tyrosine phosphatase has been used in a computational study of the reaction mechanism at the atomic level. LÄS MER

7. 5. A screen for mutations affecting PNS development in Drosophila identifies the trim gene, dappled

   Författare :Fergal O'Farrell; Per Kylsten; Jan-Åke Gustafsson; Stefan Thor; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : The peripheral nervous system of Drosophila melanogaster contains a variety of sense organs, ranging from the relatively simple four celled bristle organ to the more complex compound eye. The development of each organ type is well described, providing a useful backdrop for functional studies of genes acting in one or more of the many processes involved in organogenesis. LÄS MER