Sökning: "DNA damage response"

Visar resultat 11 - 15 av 228 avhandlingar innehållade orden DNA damage response.

  1. 11. UV-induced DNA damage in humans

    Författare :Vladimir J Bykov; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :32P-HPLC; photoproducts; DNA repair; solar simulated radiation; erythema; sunscreens; humans;

    Sammanfattning : Ultraviolet radiation is considered to be the most harmful part of solar energy affecting man. The depletion of the ozone layer around the Earth increases the total exposure to UV-light. The incidence of skin cancer in man has been shown to be associated with exposure to solar radiation, especially to UV-light. LÄS MER

  3. 12. Measurements of the DNA double-strand break response

    Författare :Aida Muslimovic; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DSB response; cancer patients; H2AX phosphorylation;

    Sammanfattning : Radiotherapy and some chemotherapeutic drugs kill cancer cells by induction of the extremely toxic DNA double-strand breaks (DSBs). Measurements of the DSB response in patients during therapy could allow personalized dosing to improve tumor response and minimize side effects. LÄS MER

  4. 13. DNA-dependent protein kinase in human cells

    Författare :Annahita Sallmyr; Malmö Klinisk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzymology; virology; mycology; mykologi; virologi; Proteiner; enzymologi; bacteriology; Microbiology; Sjögren s syndrome; HL60; PMN; Ku86v; Ku86; DNA-PK; DNA DSBs; NHEJ; Proteins; Mikrobiologi; bakteriologi;

    Sammanfattning : DNA-dependent protein kinase (DNA-PK) is a holoenzyme consisting of a regulatory subunit, the heterodimeric Ku70/86, and a catalytic subunit known as DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK takes part in a number of cellular functions including growth control, immunoglobulin gene rearrangement and DNA repair. LÄS MER

  5. 14. Factors modifying cellular response to ionizing radiation

    Författare :Lei Cheng; Andrzej Wojcik; Siamak Haghdoost; Lovisa Lundholm; Penelope A. Jeggo; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Radiation biology; DNA damage; gene expression; alpha particles; X-rays; mixed beams; gamma rays; hypothermia; dose rate.; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Many physical factors influence the biological effect of exposure to ionizing radiation, including radiation quality, dose rate and temperature. This thesis focuses on how these factors influence the outcome of exposure and the mechanisms behind the cellular response. LÄS MER

  7. 15. Measurement of sensitivity to DNA damaging agents

    Författare :Sherin T Mathew; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; intrinsic sensitivity; DNA damage; ionizing radiation; cell division;

    Sammanfattning : There is a large inter-individual variation in intrinsic sensitivity in patients receiving treatment with DNA damaging agents. Cancer therapy exemplifies this problem where patients experience varying degree of normal tissue side effects in response to radiation or chemotherapy. LÄS MER