Sökning: "HL60"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet HL60.

  1. 1. DNA-dependent protein kinase in human cells

    Författare :Annahita Sallmyr; Malmö Klinisk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzymology; virology; mycology; mykologi; virologi; Proteiner; enzymologi; bacteriology; Microbiology; Sjögren s syndrome; HL60; PMN; Ku86v; Ku86; DNA-PK; DNA DSBs; NHEJ; Proteins; Mikrobiologi; bakteriologi;

    Sammanfattning : DNA-dependent protein kinase (DNA-PK) is a holoenzyme consisting of a regulatory subunit, the heterodimeric Ku70/86, and a catalytic subunit known as DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK takes part in a number of cellular functions including growth control, immunoglobulin gene rearrangement and DNA repair. LÄS MER

  3. 2. In vitro studies on anti-leukemic effects of tetracycline's analogues and cyclophosphamide

    Författare :Mona Fares; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Leukemia is a heterogeneous group of hematological malignancies that originate from the bone marrow. Leukemias are classified as acute or chronic. Although acute leukemia affects patients of all ages, acute lymphoid leukemia is predominant in children and young adults while acute myeloid leukemia (AML) is predominant in the elderly. LÄS MER

  4. 3. Leukemia chemotherapy : experimental studies on pharmacological optimisation

    Författare :Michèle Masquelier; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Our main goal has been to identify new means to improve chemotherapy of acute leukaemia: 1. By using low-density lipoprotein (LDL) as a drug carrier to increase the selectivity of antileukemic drugs, based on high LDL uptake in acute myeloid leukemia (AML) cells. LÄS MER

  5. 4. Telomerase activity and its regulation in malignant hematopoietic cells

    Författare :Dawei Xu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :hTERT mortalization malignancy activity telomerase regulation;

    Sammanfattning : Telomerase, a multicomponent ribonucleoprotein, synthesizes TTAGGG telomeric repeats essential for the stability and integrity of chromosomes. Most normal human somatic cells exhibit undetectable telomerase activity. LÄS MER

  7. 5. Host cell responses to Helicobacter pylori secreted factors

    Författare :Raquel Garcia Lobato Tavares; Sushil Kumar Pathak; Åsa Sjöling; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Helicobacter pylori; Secreted proteins; Host cell responses; Macrophages; Apoptosis; Pro-inflammatory cytokines; MAPKs; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : The infection of the human gastric mucosa by the bacterium Helicobacter pylori can lead to the development of gastritis, gastroduodenal ulcers, and cancer. The factors that determine disease development in a small percentage of infected individuals are still not fully understood. LÄS MER