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Visar resultat 1 - 5 av 11 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Immune evasion and identification of biomarkers associated with mycobacterial infection

    Författare :John Arko-Mensah; Carmen Fernandez; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Immunologi;

    Sammanfattning : .... LÄS MER

  3. 2. Mycobacterial infection: Immune evasion, host susceptibility and immunological markers of diagnostic importance

    Författare :John Arko-Mensah; Carmen Fernandez; Francesco Dieli; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mycobacteria; Mice; Toll-like receptors; interferon gamma; immunological markers; lung; respiratory tract; susceptibility; Immunology; Immunologi; immunologi; Immunology;

    Sammanfattning : IIn the first study, we investigated the functional implications of prolonged TLR signalling on IFN-γ mediated killing of mycobacteria by murine macrophages in vitro. TLR2, but not TLR4 ligation interfered with IFN-γ mediated killing of mycobacteria in macrophages. LÄS MER

  4. 3. Bioactive leishmanicidal alkaloid molecules from Galipea longiflora Krause with immunomodulatory activity

    Författare :Jacqueline Calla-Magariños; Carmen Fernández; Marita Troye-Blomberg; Geneviève Milon; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Leishmania infection; Leishmaniasis; herbal medicine; natural products; Galipea longiflora Krause; Evanta; cytokines; IFN-gamma; dendritic cells; inflammation; meglumine antimoniate; immunologi; Immunology;

    Sammanfattning : According to WHO, leishmaniasis is endemic in 98 countries, and has been placed ninth in a global analysis of infectious diseases. Treatment of leishmaniasis is based on pentavalent antimonials but toxicity and developing resistance have been reported. LÄS MER

  5. 4. Innate and adaptive immune responses in the lungs. Contribution to protection against mycobacterial infections

    Författare :Olga Daniela Chuquimia Flores; Carmen Fernández; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Host defense against Mycobacterium tuberculosis (Mtb) is mediated by a combination of innate and adaptive immunity. In this thesis we investigated the role of components of innate system such as TLR2 signalling and alveolar epithelial cells type II (AEC II) in the immune responses against mycobacterial infections. LÄS MER

  7. 5. Role of alveolar epithelial cells in macrophage responses against mycobacterial infections

    Författare :Olga Daniela Chuquimia Flores; Carmen Fernández; Diana Boraschi; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lung; alveolar epithelial cells; macrophages; AEC-derived media; control of intracellular bacterial growth; mycobacterial infections; immunologi; Immunology;

    Sammanfattning : This thesis aimed to investigate the role of alveolar epithelial cells (AEC) on immune responses against mycobacterial infections, specifically, the role of AEC in modulating macrophage functions through the secretion of broad variety of factors.In paper I, we compared murine AEC with interstitial macrophages (PuM) in their ability to take up and control mycobacterial growth and their capacity as antigen-presenting cells. LÄS MER