Sökning: "CD8 cytotoxic T cells"

Visar resultat 6 - 10 av 102 avhandlingar innehållade orden CD8 cytotoxic T cells.

1. 6. T cells in chronic obstructive pulmonary disease

   Författare :Ester Roos-Engstrand; Anders Blomberg; Anders Bucht; Annelie F Behndig; Magnus Sköld; Claes-Göran Löfdahl; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; airway epithelium; bronchoscopy; bronchoalveolar lavage; endobronchial mucosal biopsies; inflammation; flow cytometry; T lymphocytes; CD25; CD127; FoxP3; Lung diseases; Lungsjukdomar; lungmedicin; Lung Medicine;

   Sammanfattning : Background: Tobacco smoking is the main cause of chronic obstructive pulmonary disease, COPD, but the mechanisms by which cigarette smoke induces COPD are still elusive. T lymphocytes have been implicated in the pathogenesis of the disease, but their role in the airway inflammation in COPD is not fully understood. LÄS MER

3. 7. Human intestinal T lymphocytes : a comparative analysis of phenotype and function in normal and inflamed mucosa

   Författare :Silvia Melgar; Nadine Cerf-Bensussan; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human intestinal mucosa; intraepithelial lymphocyte; lamina propria lymphocyte; γδ T cell; regulatory T cell; cytotoxicity; cytokine; basal lymphoid aggregate; ulcerative colitis; Crohn s disease;

   Sammanfattning : The epithelial lining of the gut must allow immediate contact with beneficial components as nutrients and normal microflora. At the same time it runs the constant risk of attack from pathogenic microbes and noxious agents. LÄS MER

4. 8. Lung-resident, M2e-specific CD4 T cells critically protect during influenza infection

   Författare :Ajibola Omokanye; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; influenza; vaccine; universal; heterosubtypic; M2e; CD4; Th17; ThCTL; tissue-resident; cytotoxic; single-cell RNA-seq;

   Sammanfattning : Memory CD4+ T cells are a critical component of the adaptive immune response to fight infection. However, current vaccines against influenza only focus on the other arm of adaptive immunity—triggering B cells to produce antibodies. LÄS MER

5. 9. Immune cells in pregnant uterine mucosa : functional properties, cellular composition and tissue organization

   Författare :Lucia Mincheva-Nilsson; Sten Hammarström; Rolf Kiessling; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunologically privileged site; TCR γδ cells; CD56 cells; large granular lymphocytes; immunosuppression; cytokine; interleukin; lymphoid cell cluster; intraepithelial lymphocytes; glandular epithelium; immuno electron microscopy; pregnancy; decidua; lactoferrin; lactoferrin receptor; colostrum;

   Sammanfattning : The pregnant uterus mucosa - decidua - is an "immunologically privileged" site. A semiallogeneic embryo is allowed to survive, develop, and grow while the same tissue implanted outside the uterus will be rejected. The decidua basalis, which participates in the placenta formation, is a tissue rich in lymphoid cells. LÄS MER

7. 10. Requirements for the Induction of Adaptive Immune Responses to Rotavirus

   Författare :Joy Nakawesi; Virusrekognition; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rotavirus; classical dendritic cells; Lymphoid organ hypertrophy; B cells; IgA; Retinoic acid; CD8 T cells; TLR3 and Poly I:C ;

   Sammanfattning : Rotavirus (RV) infections remain the leading cause of world-wide diarrhea-associated morbidity and mortality among children 200,000 deaths annually mostly in the low-income countries of Africa and Asia. Efficient clearance of the primary RV infection and protection from future re-infections is mediated by adaptive immune responses. LÄS MER