Sökning: "Biophysics"

Visar resultat 41 - 45 av 353 avhandlingar innehållade ordet Biophysics.

  1. 41. Structural investigation of human mitochondrial translation and off-target antibiotic binding

    Författare :Vivek Singh; Alexey Amunts; Yaser Hashem; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mitochondrial translation; mitoribosome; electron cryo-microscopy; LRPPRC-SLIRP; antibiotics; streptomycin; Biophysics; biofysik;

    Sammanfattning : Human mitochondrial translation machinery has evolved to translate 13 mitochondrial mRNAs encoding components of the oxidative phosphorylation pathway responsible for ATP production. The structural basis of human mitochondrial translation is distinct from the canonical bacterial and cytosolic translation systems. LÄS MER

  3. 42. Structure and lipid interactions of membrane-associated glycosyltransferases : Cationic patches and anionic lipids regulate biomembrane binding of both GT-A and GT-B enzymes

    Författare :Scarlett Szpryngiel; Lena Mäler; Marcelo Guerins; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; glycosyltransferase; monotopic membrane proteins; galactolipids; NMR; chitin synthase; DGD2; LPS; WaaG; MIT domain; Biophysics; biofysik;

    Sammanfattning : This thesis concerns work on structure and membrane interactions of enzymes involved in lipid synthesis, biomembrane and cell wall regulation and cell defense processes. These proteins, known as glycosyltransferases (GTs), are involved in the transfer of sugar moieties from nucleotide sugars to lipids or chitin polymers. LÄS MER

  4. 43. Fluorescence Studies of Cell Division in Escherichia coli

    Författare :Bill Söderström; Gunnar von Heijne; Jie Xiao; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; E. coli; Cell division; FtsZ; Fluorescence microscopy; FRAP; Biophysics; biofysik;

    Sammanfattning : In Escherichia coli the cell division is carried out by a large dynamic protein complex called the divisome. The divisome assembles in a two-step manner starting with the localization of the eukaryotic tubulin homologue FtsZ to the midcell. Together with other early arriving proteins FtsZ form an intermediate structure called the Z-ring. LÄS MER

  5. 44. Studies of protein structure, dynamics and protein-ligand interactions using NMR spectroscopy

    Författare :Tobias Tengel; Göran Larsson; Maria Sunnerhagen; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; 19F NMR; 2S albumin; PapD; protein-ligand interaction; structure; TFE; Yersinia; YopD; allergy; amphipathic helix; Ber e 1; Brazil nut; dynamics; FimC; LcrH; NMR screening; Biophysics; Biofysik;

    Sammanfattning : In the first part of the thesis, protein-ligand interactions were investigated using the chaperone LcrH, from Yersinia as target protein. The structure of a peptide encompassing the amphipathic domain (residue 278-300) of the protein YopD from Yersinia was determined by NMR in 40% TFE. LÄS MER

  7. 45. Membrane Induced Structure in Transmembrane Signaling Proteins and Peptides : Peptide–Lipid Interactions Studied by Spectroscopic Methods

    Författare :Sofia E. Unnerståle; Lena Mäler; Jason Schnell; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; peptide-lipid interaction; paddle domain; voltage gating; voltage sensor domain; micelle; phospholipid bicelle; solution structure; HAMP domain; nuclear magnetic resonance spectroscopy; circular dichroism spectroscopy; nonspecific interaction; Biophysics; biofysik;

    Sammanfattning : Biological membranes, defining the boundary of cells and eukaryotic organelles, are mainly composed of lipids and membrane proteins. Interactions between these lipids and proteins are needed to preserve the tight seal of the membrane, but also to induce structure for proper function in many membrane proteins. LÄS MER