Sökning: "peptide-lipid interaction"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden peptide-lipid interaction.

  1. 1. NMR Investigations of Peptide-Membrane Interactions, Modulation of Peptide-Lipid Interaction as a Switch in Signaling across the Lipid Bilayer

    Författare :Sofia Unnerståle; Lena Mäler; Göran Widmalm; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; peptide-lipid interaction; membrane mimetic; NMR; biophysics; Molecular biophysics; Molekylär biofysik; biofysik; Biophysics;

    Sammanfattning : The complexity of multi cellular organisms demands systems that facilitate communicationbetween cells. The neurons in our brains for instance are specialized in this cell-cellcommunication. LÄS MER

  3. 2. Aggregation behavior and peptide-lipid interaction in an amyloid model system

    Författare :Jon Pallbo Arvidsson; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; amyloids; peptides; lipids; NACore; aggregation; fibrillation; crystallization; self-assembly; interaction;

    Sammanfattning : Proteins constitute a major component of living cells and are essential to their function. Sometimes proteins misfold or aggregate in abnormal ways, which can give rise to diseases. Amyloids are a special type of highly ordered protein aggregates made of long intermolecular beta-sheets stacked into fibrils. LÄS MER

  4. 3. Membrane Induced Structure in Transmembrane Signaling Proteins and Peptides : Peptide–Lipid Interactions Studied by Spectroscopic Methods

    Författare :Sofia E. Unnerståle; Lena Mäler; Jason Schnell; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; peptide-lipid interaction; paddle domain; voltage gating; voltage sensor domain; micelle; phospholipid bicelle; solution structure; HAMP domain; nuclear magnetic resonance spectroscopy; circular dichroism spectroscopy; nonspecific interaction; Biophysics; biofysik;

    Sammanfattning : Biological membranes, defining the boundary of cells and eukaryotic organelles, are mainly composed of lipids and membrane proteins. Interactions between these lipids and proteins are needed to preserve the tight seal of the membrane, but also to induce structure for proper function in many membrane proteins. LÄS MER

  5. 4. Biological membrane interfaces involved in diseases : a biophysical study

    Författare :Fredrick Lindström; Gerhard Gröbner; Dick Sandström; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Solid-state NMR; DSC; Amyloid-beta peptide; Nociceptin; DMPC; DMPG; DDAB; peptide-lipid interaction; branched-chain fatty acid.; Biophysical chemistry; Biofysikalisk kemi;

    Sammanfattning : Interactions between peptides and biological lipid membranes play a crucial role in many cellular processes such as in the mechanism behind Alzheimer’s disease where amyloid-beta peptide (Abeta)is thought to be a key component. The initial step of binding between a surface active peptide and its target membrane or membrane receptor can involve a non specific electrostatic association where positively charged amino acid residues and a negatively charged membrane surface interact. LÄS MER

  7. 5. Membrane mediated aggregation of amyloid-β protein : a potential key event in Alzheimer's disease

    Författare :Marcus Bokvist; Gerhard Gröbner; Göran Lindblom; Lena Mäler; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer’s Disease; Aβ40; Circular Dichroism; NMR; Amyloids; Crowding; Peptide-Lipid Interaction; Biophysical chemistry; Biofysikalisk kemi;

    Sammanfattning : The pathogenesis of Alzheimer’s disease (AD), the most common senile dementia, is a complex process. A crucial event in AD is the aggregation of amyloid-β protein (Aβ), a cleavage product from the Amyloid Precursor Protein (APP). LÄS MER