Sökning: "Amyloid precursor protein"

Visar resultat 16 - 20 av 102 avhandlingar innehållade orden Amyloid precursor protein.

  1. 16. Characterization of the novel “Uppsala mutation” causing a familial form of early onset Alzheimer’s disease

    Författare :María Pagnon de la Vega; Martin Ingelsson; Dag Sehlin; Vilmantas Giedraitis; Gunnar Gouras; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; neurodegeneration; amyloid precursor protein; APP processing; amyloid beta; transgenic mouse model;

    Sammanfattning : The Alzheimer’s disease (AD) brain displays extracellular plaques of amyloid-β (Aβ), neurofibrillary tangles of tau and neuronal loss. The 40-42 amino acid Aβ peptide is formed from the amyloid precursor protein (APP) by β-secretase and γ-secretase, while α-secretase prevents Aβ generation. LÄS MER

  3. 17. Medin Amyloid in Human Arteries and its Association with Arterial Diseases

    Författare :Siwei Peng; Per Wstermark; Gunnar Husby; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; Amyloid; Medin; Lactadherin; Aneurysm; Aortic dissection; Temporal artery; Arteritis; Giant cell; Pre-aggregation.; Patologi; Pathology; Patologi;

    Sammanfattning : Amyloid is a form of abnormal protein aggregation within the living body. Massive deposits can lead to organ failure. There is also increasing evidence that smaller pre-amyloid aggregates exert direct toxic effects to cells. LÄS MER

  4. 18. Membrane mediated aggregation of amyloid-β protein : a potential key event in Alzheimer's disease

    Författare :Marcus Bokvist; Gerhard Gröbner; Göran Lindblom; Lena Mäler; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer’s Disease; Aβ40; Circular Dichroism; NMR; Amyloids; Crowding; Peptide-Lipid Interaction; Biophysical chemistry; Biofysikalisk kemi;

    Sammanfattning : The pathogenesis of Alzheimer’s disease (AD), the most common senile dementia, is a complex process. A crucial event in AD is the aggregation of amyloid-β protein (Aβ), a cleavage product from the Amyloid Precursor Protein (APP). LÄS MER

  5. 19. On inflammatory cytokines and β-amyloid peptides in acute and chronic neurodegeneration

    Författare :Roya Tehranian; Gianluigi Forloni; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammation; Cytokines; Amyloid; Peptides; Nerve degeneration; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

    Sammanfattning : Insults to the brain as well as neurodegenerative diseases are known to elicit inflammatory responses. Inflammation in the brain can on one hand initiate processes that are harmful to the injured tissue and exacerbate the damage, leading to neuronal degeneration and glial activation, and on the other hand activate processes that may be necessary for repair mechanisms and regeneration. LÄS MER

  7. 20. Alzheimer's disease : uncovering mechanisms for amyloid precursor protein processing and trafficking

    Författare :Saket Milind Nigam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by impairment of memory and, eventually, by disturbances in cognitive abilities. Brain regions crucial for learning and memory exhibit atrophy, but the underlying mechanisms for neurodegeneration continues to be point of debate. LÄS MER