Sökning: "Amyloid precursor protein"

Visar resultat 6 - 10 av 102 avhandlingar innehållade orden Amyloid precursor protein.

1. 6. Statin treatment and beta-Amyloid Production in Patients with Alzheimer s Disease

   Författare :Kina Höglund; Göteborgs universitet; []
   Nyckelord :Alzheimer s disease; amyloid precursor protein; beta-amyloid; cholesterol; statins; CSF;

   Sammanfattning : Alzheimer s disease (AD) is a progressive neurodegenerative disorder pathologically characterized by neurofibrillary tangles and amyloid plaques. According to the amyloid cascade hypothesis, the increased production of beta-amyloid (Abeta), derived form the amyloid precursor protein (APP), and its aggregation into plaques are key pathological events, driving neurodegeneration in AD. LÄS MER

3. 7. Processing of the amyloid precursor protein and its paralogues amyloid precursor-like proteins 1 and 2

   Författare :Linda Adlerz; Kerstin Iverfeldt; Richard Cowburn; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APP; APLP1; APLP2; Alzheimer s disease; Amyloid β-peptide; Processing; RA; BDNF; IGF-1; curcumin; PI3-K; MAPK; cdk5; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

   Sammanfattning : Alzheimer’s disease (AD) is a neurodegenerative disorder which is histopathologically characterised by amyloid plaques and neurofibrillary tangles. Amyloid plaques consist of the amyloid β-peptide (Aβ) that can form aggregates in the brain. Aβ is generated from the amyloid precursor protein (APP) through proteolytic cleavage. LÄS MER

4. 8. Amyloid precursor protein : cellular studies and animal models

   Författare :Tatjana Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by a number of neuropathological features, including extracellular deposits composed primarily of amyloid-β (Aβ) peptides. Aβ is derived from proteolysis of the amyloid precursor protein (APP) by consecutive action of β and γ-secretases. LÄS MER

5. 9. Studies of amyloid precursor protein trafficking and processing

   Författare :Shaohua Xu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Alzheimer’s disease (AD) is the most common form of neurodegenerative disease that slowly impairs memory and thinking abilities. Abnormal accumulation and aggregation of amyloid β peptides (Aβ), derived from proteolytic cleavage of the amyloid precursor protein (APP), is thought to be one of the critical triggers in the pathogenesis. LÄS MER

7. 10. The amyloid-β precursor protein (APP) and its adaptor protein Fe65 : Two key players in Alzheimer’s disease

   Författare :Preeti Menon; Anna-Lena Ström; Thorsten Müller; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; APP; Fe65; Meprinβ; α-secretase; APP processing; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the abnormal accumulation and aggregation of amyloid beta (Aβ) peptides within the brain. Generation of Aβ occur when the amyloid-beta precursor protein (APP) is proteolytically processed by β- and then γ-secretase in the amyloidogenic pathway. LÄS MER