Sökning: "Neurological disease"

Visar resultat 1 - 5 av 317 avhandlingar innehållade orden Neurological disease.

1. 1. Proteomics in neurological disease

   Författare :Jan Ottervald; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Neurodegenerative and neuroinflammatory diseases are conditions affecting the central nervous system that in the end have dramatic impacts on the affected individuals and their families. Today, large efforts are made to understand the disease origin and progression. LÄS MER

3. 2. Diet and common neurological disorders: cohort studies on dementia, Parkinson’s disease, and stroke

   Författare :Erika Olsson; Susanna C. Larsson; Liisa Byberg; Lena Kilander; Emily Sonestedt; Uppsala universitet; []
   Nyckelord :diet; dietary pattern; Healthy Diet Indicator; Mediterranean diet; low carbohydrate; vitamin D; 25-hydroxyvitamin D; Mendelian randomization; milk; fermented milk; epidemiology; cohort study; Alzheimer’s disease; dementia; cognitive impairment; Parkinson’s disease; stroke; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Risk factors for dementia, Parkinson’s disease, and stroke have been widely studied but there are still research gaps concerning the role of diet for the development of these diseases. The overall aim of this thesis was to investigate whether various aspects of diet are associated with common disorders and diseases in the brain. LÄS MER

4. 3. Gene Therapy for Neurological Disorders

   Författare :Jan Tönnesen; Lund Neurologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epileptiform activity; striatum; organotypic culture; electrophysiology; Wnt5a; synaptic connectivity.; cell transplantation; hippocampus; neural stem cells; epilepsy; functional integration; Parkinson’s disease; optogenetics; Gene therapy;

   Sammanfattning : Gene therapy is an attractive strategy for neurological disorders, such as Parkinson’s disease and epilepsy, for several reasons. Introduction of genes with a therapeutic potential can be achieved locally, by accurate injections in the compromised tissue, and release of a transgene therapeutic substance can be regulated by the surrounding host neural circuitry. LÄS MER

5. 4. On potentials and limitations of perfusion MRI in neurological disorders

   Författare :Markus Fahlström; Mark Lubberink; Adam Espe Hansen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurological disease; MRI; Perfusion; 15O-water PET; Medicinsk radiofysik; Medical Radiophysics;

   Sammanfattning : Cerebral perfusion outlines several parameters which describe the status of cerebral haemodynamics. Numerous neurological diseases affect cerebral perfusion, thus the importance of diagnostic measurements. LÄS MER

7. 5. Cerebrum Illuminans : Mass Spectrometric Analysis of Protein and Peptide Dynamics in Neurological Diseases

   Författare :Jörg Hanrieder; Jonas Bergquist; Malin Andersson; Ulf Hellman; Alma Burlingame; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry; central nervous system; neurological disease; proteomics; MALDI imaging; Analytical chemistry; Analytisk kemi; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

   Sammanfattning : The human brain (lat. cerebrum) is the most complex and heterogeneous organ in the human body. It is involved in a great number of body functions like movement, touch sensing, vision, hearing, smelling, hormone regulation and many more. In no other organ, the molecular communication mechanisms between different cells are so poorly understood. LÄS MER