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Visar resultat 1 - 5 av 6 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Assessment of attenuation correction methods for quantitative neuro-PET/MR

   Författare :Joao M. Sousa; Mark Lubberink; Lieuwe Appel; Håkan Ahlström; Mathias Engström; Ivo Rausch; Radiologi Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET; MRI; attenuation correction; 68Ge transmission; quantification; 11C-PE2I; MRAC; DAT; CBF; Medicinsk radiofysik; Medical Radiophysics;

   Sammanfattning : Hybrid PET/magnetic resonance (MR) can provide physiological, functional, and structural information simultaneously, facilitating research in neurological disorders. For quantitative PET, correction for photon attenuation (AC) is necessary. LÄS MER

3. 2. Towards Clinical Implementation of Dynamic Positron Emission Tomography in Neurodegenerative Diseases

   Författare :My Jonasson; Mark Lubberink; Lieuwe Appel; Jens Sörensen; Michel Koole; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Positron emission tomography; PET; Molecular imaging; Quantification; Kinetic modelling; Parametric images; Alzheimer’s disease; Parkinson’s disease; Radiology; Radiologi;

   Sammanfattning : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common neurodegenerative disorders worldwide. Positron emission tomography (PET), together with suitable biomarkers, can aid in the clin-ical evaluation as well as in research investigations of these diseases. LÄS MER

4. 3. Attention-deficit/hyperactivity disorder : alterations of motor behaviour and dopaminergic transmission

   Författare :Aurelija Jucaite; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :AD HD; DCD; neurodevelopmental disorder; PET; dopamine transporter; dopamine D2 receptors; raclopride; striatum; midbrain; anticipatory postural adjustments;

   Sammanfattning : Altered catecholaminergic neurotransmission in the brain has long been thought to be of importance in the regulation of motor behavior and cognitive performance in children who had symptoms of distractability, impulsivity and clumsiness. The dopamine theory of AD/HD has mainly been substantiated by: i) the effects of psychostimulants, which target the dopamine transporter (DAT), and thereby reduce impulsiveness and inattentiveness, increase the striatal cerebral blood flow and functional activity, and ii) the evidence from linkage studies associating the AD/HD syndrome with allelic variations of genes encoding the dopamine transporter and, possibly, the dopamine D4 receptors. LÄS MER

5. 4. Imaging serotonin and dopamine transporters in social anxiety disorder : Characterization, treatment and expectancy effects

   Författare :Olof Hjorth; Tomas Furmark; Andreas Frick; Eduard Maron; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; PET; serotonin; dopamine; placebo; SSRI; CBT; MRI; Psychology; Psykologi; Psychiatry; Psykiatri; Radiology; Radiologi;

   Sammanfattning : The monoamines serotonin and dopamine are likely to be involved in the pathophysiology of social anxiety and other affective disorders, but their respective contributions and putative interactions in the causes and cures of these disorders are still not well understood. It is also largely unknown if and how expectations of treatment success affect brain neurochemistry and neural activations, and if expectations interact with antidepressants like selective serotonin reuptake inhibitors (SSRIs). LÄS MER

7. 5. PET studies of the dopamine system in relation to cognitive functions

   Författare :Nina Erixon-Lindroth; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The human brain is intricately designed to execute cognitive functions such as perception, attention, memory and learning. Deficits in cognitive functions accompany major psychiatric disorders such as schizophrenia, attention deficit hyperactivity disorder and Parkinson s disease. LÄS MER