Sökning: "Molecular imaging"
Visar resultat 1 - 5 av 475 avhandlingar innehållade orden Molecular imaging.
1. Imaging the molecular pathways of neurodegeneration : New pathologies of SCA7
Sammanfattning : Spinocerebellar Ataxia type 7 (SCA7) is a genetic neurodegenerative disease with lethal outcome that affects the cerebellum and retina of patients. This thesis focuses on characterising molecular pathological pathways that cause toxicity and cell death in SCA7. LÄS MER
2. Abdominal Aortic Aneurysm : Molecular Imaging Studies of Pathophysiology
Sammanfattning : The pathological process behind abdominal aortic aneurysm (AAA) formation is poorly understood and difficult to study. The aim of the thesis was to study the pathophysiology of AAA formation with positron emission tomography (PET) technology, a molecular imaging technique, allowing in vivo studies of pathophysiological changes. LÄS MER
3. Coherent Diffractive Imaging with X-ray Lasers
Sammanfattning : The newly emerging technology of X-ray free-electron lasers (XFELs) has the potential to revolutionise molecular imaging. XFELs generate very intense X-ray pulses and predictions suggest that they may be used for structure determination to atomic resolution even for single molecules. LÄS MER
4. Preclinical Molecular Imaging using Multi-Isotope Digital Autoradiography - Techniques and Applications
Sammanfattning : Molecular imaging, both in vivo and ex vivo, is playing an increasingly important role in preclinical medical research. When using radionuclide-labeled tracers, e.g. in the development of radiopharmaceuticals for diagnostic imaging or for radionuclide therapy, quantitative in vivo imaging can be performed using emission tomography. LÄS MER
5. Engineering of Affibody molecules for Radionuclide Molecular Imaging and Intracellular Targeting
Sammanfattning : Affibody molecules are small (7 kDa) affinity proteins of non-immunoglobulin origin that have been generated to specifically interact with a large number of clinically important molecular targets.In this thesis, Affibody molecules have been employed as tracers for radionuclide molecular imaging of HER2- and IGF-1R-expressing tumors, paper I-IV, and for surface knock-down of EGFR, paper V. LÄS MER
