Sökning: "Ülo Langel"

Visar resultat 36 - 40 av 42 avhandlingar innehållade orden Ülo Langel.

1. 36. Rational design and applications of cell-penetrating peptides

   Författare :Jakob Regberg; Ülo Langel; Amelie Eriksson Karlström; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Cell-penetrating peptides are peptides capable of translocating the cellular membrane and entering the cell, either alone or together with a cargo. Potential applications of cell-penetrating peptides include drug delivery and gene therapy. LÄS MER

3. 37. Delineating Ligand-Receptor Interactions and the Design of Subtype Selective Galanin Receptor Ligands

   Författare :Johan Runesson; Ülo Langel; Barbara Kofler; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : We now celebrate that it is 30 years since galanin was first isolated. During these three decades galanin has been identified in numerous tissues and physiological processes, and in an abundant number of species. In the nervous system galanin primarily displays a modulatory role. LÄS MER

4. 38. Galanin receptor ligands

   Författare :Johan Runesson; Ülo Langel; Lena Mäler; Stockholms universitet; []
   Nyckelord :Galanin; GALP; GPCR; Agonist; GalR; Chimeric peptide; Inositol phosphate production; Receptor specificity; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

   Sammanfattning : In the nervous system galanin primarily displays a modulatory role. The galaninergic system consists of a number of bioactive peptides with a highly plastic expression pattern and three different receptors. The lack of receptor subtype selective ligands and antibodies have severely hampered the charac-terization of this system. LÄS MER

5. 39. Cell-penetrating peptides targeting glioblastomas for nucleic acid delivery in the blood-brain barrier model

   Författare :Artita Srimanee; Ülo Langel; Ines Neundorf; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Blood-brain barrier model; nucleic acid delivery; glioblastomas; cell-penetrating peptides; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Glioblastoma multiforme is the most aggressive form of malignant brain tumor with poor prognosis. The efficacy of brain cancer treatment by chemotherapeutics is limited by the blood-brain barrier (BBB) which allows less than 2% of the small molecules and blocks almost all the macromolecules to transport into the brain. LÄS MER

7. 40. Peptide-based delivery to glioblastoma cells studied by the blood-brain barrier model

   Författare :Artita Srimanee; Ülo Langel; Ing-Marie Nilsson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; peptide-based delivery; blood-brain barrier; glioblastoma; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Crossing the blood-brain barrier (BBB) is a great challenge for delivery of highly charged macromolecules such as nucleic acids and proteins to the brain. Cell-penetrating peptides (CPPs) are promising vectors to deliver various cargoes ranging from small molecules to large molecules such as antibodies, proteins, and nucleic acids. LÄS MER