Sökning: "transgenerational"

Visar resultat 6 - 10 av 28 avhandlingar innehållade ordet transgenerational.

  1. 6. Polycystic ovary syndrome and maternal obesity : does it programme transgenerational dysfunction?

    Författare :Haojiang Lu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : As one of the most prevalent syndromes among reproductive-aged women, polycystic ovary syndrome (PCOS) manifests with endocrine, reproductive and metabolic disturbances. However, the etiology of PCOS is yet to be fully understood. Here in this thesis, we set out to understand whether and how PCOS can be transmitted to the future generations. LÄS MER

  3. 7. MHC diversity and expression in a songbird : Temporal and transgenerational variation

    Författare :Samantha Mellinger; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MHC diversity; MHC-I gene expression; songbirds; genome assembly; amplicon HTS; temporal variation; family data; great reed warbler Acrocephalus arundinaceus ;

    Sammanfattning : The immune system is of central importance to clear-off pathogens in order to keep an organism healthy. In vertebrates, the Major Histocompatibility Complex (MHC) is a genomic region that holds key genes involved in adaptive immunity and in particular in the antigen presenting process. LÄS MER

  4. 8. Environmental regulation of metabolism : from transgenerational effects of nutrition to acute effects of exercise

    Författare :Petter Alm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The incidence of metabolic disease has risen rapidly in the last half-century leading to both individual suffering and a burden to society. The importance of physical activity for metabolic health is well known. Furthermore, there is increasing evidence that parental food choice and obesity can affect the metabolic health of future generations. LÄS MER

  5. 9. Finding the right one : Host-plant choice and its transgenerational influence on behaviour and life-history traits in Spodoptera littoralis

    Författare :Axel Rösvik; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Herbivorous insects have an intricate relationship with their host plants, which they use as food, oviposition substrate, as well as a rendezvous site for mating. For generalist herbivorous insects that have a wide host range, finding a suitable host plant in a complex environment is of great importance for their offspring’s development and survival. LÄS MER

  7. 10. How can an organism´s life experience affect their descendants? Insights from epigenetic and transgenerational effects of chemical exposure in zebrafish

    Författare :Mélanie Blanc; Steffen Keiter; Joëlle Rüegg; Xavier Cousin; Nikolai Scherbak; Michael K. Skinner; Örebro universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Neurotoxicity; behavior; RNA-Seq; RRBS; TEI; permethrin; PCBs; PBDEs; coumarin 47;

    Sammanfattning : Environmental pollution causes approx. 10% of human diseases, and some develop in the progeny because of parental exposure. Effects passed on to subsequent generations may be a consequence of genetic mutations, or of inherited changes in epigenetic patterns. LÄS MER