Sökning: "transcript"

Visar resultat 16 - 20 av 324 avhandlingar innehållade ordet transcript.

  1. 16. Molecular mechanisms involved in glioma cell interactions in vitro and studies of PDGF B transcript variants

    Författare :Susanne Heller; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Tumor heterogeneity; glioma; differential display; PDGF B; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Glioblastoma multiforme is a malignant brain tumor characterized by heterogeneity.Interactions between heterogeneous tumor cells are supposed to affect the behavior of awhole tumor cell population. LÄS MER

  3. 17. The odyssey of MYC transcript from the nucleus to the cytoplasm : the molecular mechanism of the gene gating in human cancer cells

    Författare :Mirco Martino; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pathological expression of the MYC oncogene is a common denominator in a wide range of cancers and is linked with abnormal cell proliferation. To achieve this status, the MYC gene benefits from being embedded in a region rich in enhancers and super-enhancers that are often absent in the normal cell counterparts. LÄS MER

  4. 18. The role of CART in islet function

    Författare :Mia Abels; Neuroendokrin cellbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cocaine- and amphetamine-regulated transcript; CART; Diabetes; T2D; Human islets; Glucagon; Insulin; Adipocyte;

    Sammanfattning : Diminished insulin secretion and dysregulated glucagon secretion are key features of type 2 diabetes (T2D). The overall aim of this thesis was to study the role of cocaine- and amphetamine-regulated transcript (CART) in islet cell function and how CART regulates glucose homeostasis. LÄS MER

  5. 19. Central and Peripheral Neuroendocrine Factors in Cancer-Associated Anorexia and Cachexia

    Författare :Jonathan R Burgos; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer anorexia-cachexia syndrome; inflammation; TSH receptor; cocaine- and amphetamine-regulated transcript; nesfatin-1; CRH; hypothalamus; brainstem; MCG101;

    Sammanfattning : Cancer anorexia-cachexia syndrome (CACS) develops in response to tumor-host biochemical interactions. A loss of appetite (anorexia) and increased metabolism results in a progressive wasting of adipose and skeletal muscle tissues (cachexia). LÄS MER

  7. 20. Neuropeptide circuitries regulating food and water intake

    Författare :Christian Broberger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :agouti gene-related protein; anorexia mutation; arcuate nucleus; cholecystokinin; cocaine- and amphetamine-regulated transcript; coexistence; confocal microscopy; dorsal root ganglion; feeding; hypocretin; immunohistochemistry; in situ hybridization; melanin-concentrating hormone; nodose ganglion; nucleus tractus solitaxii; orexin; paraventricular nucleus; satiety; sensory neurones; pro-opiomelanocortin; vagus nerve;

    Sammanfattning : An adequate supply of nutrients through food intake is critical for survival, as evidenced by disorders such as obesity and anorexia, which in the long run may be life-threatening. Feeding behaviour is ultimately controlled by interacting neuronal populations in the brain. LÄS MER