Sökning: "Tumor heterogeneity"
Visar resultat 1 - 5 av 105 avhandlingar innehållade orden Tumor heterogeneity.
Sammanfattning : Glioblastoma multiforme (GBM) is the most common and lethal form of primary brain tumor that mainly affects adults. GBM displays remarkable intra- and inter-tumoral heterogeneity and contains a subpopulation of cells named glioma stem cells that is believed to be responsible for tumor maintenance, progression and recurrence. LÄS MER
Sammanfattning : Cancer is a diverse disease with large variations between tumor types and patients regarding tumor progression and prognosis. Additionally, most individual tumors are heterogeneous, containing subpopulations of cells with various characteristics. LÄS MER
Sammanfattning : For the diagnosis of prostate cancer, there is a need to develop biopsy strategies, that give representative information both for detection of cancer and for assessment of prognostic indicators.In 80 men, transrectal core biopsies from 10 standardized positions were taken before radical prostatectomy. LÄS MER
Sammanfattning : This thesis concerns various aspects of somatic mosaicism and genetic intratumor heterogeneity in childhood cancer.In paper I, I show that aneuploidy in itself does not lead to the level of chromosomal instability that is typically seen in malignant cells. This finding strongly argues against the so called autocatalytic theory of carcinogenesis. LÄS MER
Sammanfattning : In this Thesis, we have developed a microtechnology-based method for culturing and visualizing high numbers of individual cells and cell-cell interactions over extended periods of time. The foundation of the device is a silicon-glass multiwell microplate (also referred as microchip) directly compatible with fluorescence microscopy. LÄS MER