Sökning: "tissue-resident macrophages"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden tissue-resident macrophages.

1. 1. Macrophages in Crohn's Disease: lnnate immune cellular and molecular mechanisms driving intestinal inflammation and fibrosis

   Författare :Frida Gorreja; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; macrophages; inflammatory macrophages; tissue-resident macrophages; efferocytosis; innate immunity; myeloid cells; fibroblasts; fibrosis; inflammasomes; Crohn´s disease; inflammatory bowel diseases; digestive diseases; mucosa immunology; intestinal immunity; intestinal inflammation; serum systemic inflammation; microbiota; metabolites;

   Sammanfattning : Macrophages and their interactions with the lamina propria and luminal microenvi-ronment are crucial in the pathogenesis of Crohn´s disease (CD), a chronic inflamma-tory disease with a strong inflammatory innate immune involvement. Therefore, in-terpreting macrophage activity in the intestinal microenvironment may identify treatment targets beneficial for at least a subgroup of patients. LÄS MER

3. 2. Monocytes and macrophages, with a focus of Crohn's disease

   Författare :Susanne Thiesen; Internmedicin - epidemiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Crohn s disease; Cystatin C; Cytokines; Intestine; Macrophages; Monocytes; Gene-expression;

   Sammanfattning : Monocytes and macrophages are part of the body’s first line of defense, eliminating pathogens by phagocytosis or by releasing a broad array of inflammatory mediators, such as cytokines, chemokines and proteases. In humans, three subsets of monocytes are described with seemingly different functions. LÄS MER

4. 3. Macrophages and neutrophils in tissue homeostasis and recovery from ischemic injury

   Författare :Kristel Parv; Mia Phillipson; Gustaf Christoffersson; Per-Ola Carlsson; Stephen Jenkins; Uppsala universitet; []
   Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; macrophages; neutrophils; hindlimb ischemia; ischemic disease; mural cells; diabetes mellitus; postnatal β cell maturation.;

   Sammanfattning : Neutrophils and macrophages have functions beyond protection against pathogens. The overall aim of the work presented in this thesis was to identify novel tasks for these innate immune cells in maintaining homeostasis. LÄS MER

5. 4. Studies of the Pancreas: Implications for Type 1 Diabetes Aetiology

   Författare :Peter Seiron; Oskar Skog; Michele Solimena; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreas; Type 1 Diabetes; Insulitis; Beta cells; Immunology; Tissue resident memory T cells; Islets of Langerhans; Endocrinology and Diabetology; Endokrinologi och Diabetologi; Immunologi; Immunology;

   Sammanfattning : Type 1 diabetes (T1D) is a disease of severe insulin deficiency through loss of β cells in the endocrine pancreas. The T1D dogma maintains that a precipitating event unleashes autoimmunity in at-risk individuals, often measured through autoantibodies against β cell antigens. LÄS MER

7. 5. The role of liver myeloid cells in obesity and metabolic disease

   Författare :Emelie Barreby; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Macrophages are tissue resident cells with diverse phenotypes and functions depending on their origin, localization and physiological context. In the liver, their main functions are to detoxify the blood from pathogens, debris and metabolic waste arriving to the liver through the systemic and portal circulation. LÄS MER