Sökning: "mural cells"
Visar resultat 1 - 5 av 19 avhandlingar innehållade orden mural cells.
1. Macrophages and neutrophils in tissue homeostasis and recovery from ischemic injury
Sammanfattning : Neutrophils and macrophages have functions beyond protection against pathogens. The overall aim of the work presented in this thesis was to identify novel tasks for these innate immune cells in maintaining homeostasis. LÄS MER
2. On macrophage contributions to tissue homeostasis : New insights on pancreas development and healing of ischemic injury
Sammanfattning : Besides providing host defence against innumerable threats, macrophages display additional key functions for preservation of tissue homeostasis. This thesis includes four studies that explore novel macrophage functions in both the development of islets of Langerhans and healing of ischemic injury in mice. LÄS MER
3. The role of PDGF-B in brain blood vessels
Sammanfattning : The development of blood vessels is dependent on several molecular cues to form properly. A functional PDGF-B/PDGFR-b signaling is paramount for the investment of mural cells, that provide with support, to the developing vasculature. LÄS MER
4. Phenotypic and functional analysis of the mesenchymal stromal cell compartment in the thymus
Sammanfattning : T cells are key cellular components of the adaptive immune system that play a critical role in our defense against pathogens and cancer but also contribute to pathology in the setting of chronic inflammation and autoimmunity. The thymus constitutes the body's major T cell production site, where bone marrow-derived progenitors migrate in a co-ordinated fashion through anatomically distinct cortical and medullary regions that are composed of epithelial and mesenchymal stromal elements. LÄS MER
5. From endothelial cells to the vascular network : How cell migration and proliferation are orchestrated to build lymphatic vessels
Sammanfattning : Lymphatic endothelial cells (LECs) migrate across body to form a branched network, which is crucial for fluid drainage and immune cell trafficking of the tissues. However, the molecular mechanisms behind the spatiotemporal regulation and fine-tuning of LEC migration remain largely unknown. LÄS MER