Sökning: "postnatal β cell maturation."
Hittade 3 avhandlingar innehållade orden postnatal β cell maturation..
1. On macrophage contributions to tissue homeostasis : New insights on pancreas development and healing of ischemic injury
Sammanfattning : Besides providing host defence against innumerable threats, macrophages display additional key functions for preservation of tissue homeostasis. This thesis includes four studies that explore novel macrophage functions in both the development of islets of Langerhans and healing of ischemic injury in mice. LÄS MER
2. Macrophages and neutrophils in tissue homeostasis and recovery from ischemic injury
Sammanfattning : Neutrophils and macrophages have functions beyond protection against pathogens. The overall aim of the work presented in this thesis was to identify novel tasks for these innate immune cells in maintaining homeostasis. LÄS MER
3. Fishing for small molecules to treat diabetes, from a beta cell perspective
Sammanfattning : Maintenance of glucose homeostasis necessitates a precise control of insulin secretion. Pancreatic β cells sense fluctuation of blood glucose and secret insulin in response. However, functional β cell mass is decreased in diabetes. Here, to recover functional β cell mass, we use zebrafish as a model to perform in vivo drug discovery. LÄS MER