Sökning: "Tissue resident memory T cells"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden Tissue resident memory T cells.

1. 1. Lung-resident, M2e-specific CD4 T cells critically protect during influenza infection

   Författare :Ajibola Omokanye; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; influenza; vaccine; universal; heterosubtypic; M2e; CD4; Th17; ThCTL; tissue-resident; cytotoxic; single-cell RNA-seq;

   Sammanfattning : Memory CD4+ T cells are a critical component of the adaptive immune response to fight infection. However, current vaccines against influenza only focus on the other arm of adaptive immunity—triggering B cells to produce antibodies. LÄS MER

3. 2. Resident T cells steer tissue responses in human skin

   Författare :Borislav Ignatov; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The human skin constitutes a biological barrier against threats to the body from the surrounding environment. Tissue-resident memory cells (TRM) reside in the skin and provide local memory of previous encounters with microbes and pathogens, are poised to promptly eliminating infected cells and elicit tissue-wide defense state. LÄS MER

4. 3. Studies of the Pancreas: Implications for Type 1 Diabetes Aetiology

   Författare :Peter Seiron; Oskar Skog; Michele Solimena; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreas; Type 1 Diabetes; Insulitis; Beta cells; Immunology; Tissue resident memory T cells; Islets of Langerhans; Endocrinology and Diabetology; Endokrinologi och Diabetologi; Immunologi; Immunology;

   Sammanfattning : Type 1 diabetes (T1D) is a disease of severe insulin deficiency through loss of β cells in the endocrine pancreas. The T1D dogma maintains that a precipitating event unleashes autoimmunity in at-risk individuals, often measured through autoantibodies against β cell antigens. LÄS MER

5. 4. Resident T cells in human skin : functional heterogeneity and clinical implications

   Författare :Stanley Sing Hoi Cheuk; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The skin forms a critical barrier against the external environment and is therefore frequently challenged by infections and subjected to immune-mediated diseases as well as malignancies. The Tissue-Resident Memory T (TRM) cell is a subset of T cells that resides at sites of previous infection in the skin and other epithelial tissues. LÄS MER

7. 5. Composition and maintenance of skin resident T-cells in health and disease

   Författare :Elena Hoffer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Tissue-resident memory T cells (TRM) reside in healthy skin at sites of previous infections. Upon re-infection, TRM cells rapidly respond by initiating tissue inflammation and exert effector functions to eliminate pathogens. TRM cells are potent effector cells and as such, they are key players in focal inflammatory skin diseases. LÄS MER