Sökning: "tissue tropism"

Visar resultat 6 - 10 av 13 avhandlingar innehållade orden tissue tropism.

  1. 6. Mechanisms involved in adenovirus binding to and infection of host cells

    Författare :Cecilia Nyberg; Niklas Arnberg; Pierre Boulanger; Umeå universitet; []
    Nyckelord :Adenovirus; binding; infection; lactoferrin; coagulation factor IX and X; fiber; MEDICINE; MEDICIN;

    Sammanfattning : The adenovirus (Ad) family consists of 52 different human types, which are divided into seven species (A-G). Human Ads cause disease in the respiratory tract, lymphoid tissue, intestine, urinary tract, and/or in the eye. LÄS MER

  3. 7. A preclinical therapy model for childhood neuroectodermal tumours

    Författare :Isabell Hultman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Childhood cancers show fundamental differences to most common adult solid tumours in their cancer-causing genetics, cell biology and their local tissue microenvironment. Effective treatments will be attainable when the molecular events that are specific to childhood tumourigenesis are better understood. LÄS MER

  4. 8. Enterovirus Implications in Type 1 Diabetes

    Författare :Monika Hodik; Hober didier; Uppsala universitet; []
    Nyckelord :Enterovirus; Coxsackie B virus; Type 1 diabetes; Pancreatitis;

    Sammanfattning : Human enteroviruses (HEVs), particularly Coxsackie B viruses (CVBs), might trigger the onset of type 1 diabetes (T1D), either by direct infection of the insulin-producing beta-cells or by an indirect inflammatory response. The overall aim of this thesis was to study the tropism of HEVs in isolated human pancreatic cell clusters in vitro including virus effects on islet function, gene-expression and ultrastructure. LÄS MER

  5. 9. Phenotype and function of intestinal CD103+ dendritic cells

    Författare :Elin Jaensson Gyllenbäck; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD103; dendritic cell; CX3CR1; small intestine; MLN; CCR9; Vitamin A; retinoic acid;

    Sammanfattning : Mucosal tissues such as the intestine present an enormous surface area to the outside environment and are continually exposed to foreign antigens in food and microflora. Thus, the intestinal mucosa must must remain tolerant to these innocuous antigens while at same time be able to mount effective immune responses to pathogens. LÄS MER

  7. 10. Inflammatory Mediators and Enterovirus Infections in Human Islets of Langerhans

    Författare :Annika Moëll; Gun Frisk; Olle Korsgren; Bo Nilsson; Outi Vaarala; Uppsala universitet; []
    Nyckelord :Immunology; diabetes; islets of Langerhans; enterovirus; inflammatory mediators; cytokines; nicotinamide; Immunologi;

    Sammanfattning : Type 1 diabetes (T1D) is due to a selective loss of the insulin producing β-cells. However, the process responsible for this loss is still unknown. There is accumulating evidence that enteroviruses (EVs) are involved in T1D. In addition to direct virus-induced cytolysis, EVs could facilitate β-cell destruction by inducing inflammatory cytokines. LÄS MER