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Visar resultat 1 - 5 av 41 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Konstitueringen av ett vetenskapligt begrepp : Exemplet - det manliga klimakteriet

    Författare :Adam Droppe; Nora Räthzel; Björn Söderfeldt; Thomas Brante; Umeå universitet; []
    Nyckelord :SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; andropause; sociology of science; male gender; testosterone; profession of medicine; big pharma; research policy; feminism; development of science; Late Onset Hypogonadism; the aging male; andrology; andropaus; vetenskapssociologi; testosteron; medicinsk profession; läkemedelsindustri; feminism; forskningspolitik; andrologi; manligt genus;

    Sammanfattning : How are new scientific concepts of illnesses and disorder formed? The last fifty years have seen a dramatic increase in new diagnoses incorporated into medical manuals. The concept of the male menopause, or the andropause diagnosis, is suitable for studying how medical knowledge is produced, since it has alternated between being and not being part of the acknowledged medical knowledge since the beginning of the 19th century, when it was originally launched. LÄS MER

  3. 2. On Aging, Behavior and the Role of PA28αβ in Protein Homeostasis

    Författare :Julia Adelöf; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aggregation prevention; Aging; Animal ethics; Cataract; Exploratory behavior; F2 hybrid mice; Healthy aging; Learning and memory; PA28αβ; Proteasome capacity; Sex comparisons; Water-based behavioral tests;

    Sammanfattning : As life expectancy increases, understanding challenges related to the processes of aging are more relevant than ever. Common age-related diseases progress as consequences of accumulative protein damage and protein aggregates. LÄS MER

  4. 3. Haploid selection in animals : Exploring the fitness consequences and underlying mechanisms

    Författare :Ghazal Alavioon; Simone Immler; Tommaso Pizzari; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; sperm; evolution; haploid selection; reproductive aging; fitness;

    Sammanfattning : A consequence of sexual reproduction in eukaryotes is the evolution of a biphasic life cycle with alternating diploid and haploid gametic phases. While our focus in evolutionary biology is on selection during the diploid phase, we know relatively little about selection occurring during the haploid gametic stage. LÄS MER

  5. 4. Methods development for the investigation of the mammalian genome radial architecture : the quantitative side

    Författare :Gabriele Girelli; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nucleus of mammalian cells cradles the genome, an ensemble of nucleic acid macromolecular polymers that store information in a physical form. For a cell to perform life-sustaining processes, reading and utilizing the information encoded in the genome monomers’ sequence is necessary. LÄS MER

  7. 5. Regulation of aortic wall mechanics and stress : An experimental study in man

    Författare :Håkan Åstrand; Toste Länne; Matts Karlsson; Martin Björck; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aorta; wall stress; remodeling; IMT; gender; diabetes mellitus; aging; collagen; elastin; Vascular surgery; Kärlkirurgi;

    Sammanfattning : The abdominal aorta (AA) in man is a vulnerable artery prone to atherosclerosis as well as aneurysmatic dilation. The underlying aortic composition, mechanical properties as well as the mechanisms responsible for age-related changes and vascular disease are however largely unknown. LÄS MER