Sökning: "PA28αβ"

Hittade 2 avhandlingar innehållade ordet PA28αβ.

1. 1. On Aging, Behavior and the Role of PA28αβ in Protein Homeostasis

   Författare :Julia Adelöf; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aggregation prevention; Aging; Animal ethics; Cataract; Exploratory behavior; F2 hybrid mice; Healthy aging; Learning and memory; PA28αβ; Proteasome capacity; Sex comparisons; Water-based behavioral tests;

   Sammanfattning : As life expectancy increases, understanding challenges related to the processes of aging are more relevant than ever. Common age-related diseases progress as consequences of accumulative protein damage and protein aggregates. LÄS MER

3. 2. Investigating the activation and regulation of the proteasome : an essential proteolytic complex

   Författare :Patrick Masson; Patrick Young; Marcus Groettrup; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Proteasome; PA28gamma; Transcriptional regulation; Drosophila; 26S; Molecular biology; Molekylärbiologi;

   Sammanfattning : The proteasome is a major non-lysosomal proteolytic complex present in eukaryotic cells and has a central role in regulating many protein levels. The complex has been shown to participate in various intracellular pathways including cell cycle regulation or quality control of newly synthesized proteins and many other key pathways. LÄS MER