Sökning: "the Crabtree effect"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden the Crabtree effect.

1. 1. Constraint-based modeling of metabolism - interpreting predictions of growth and ATP synthesis in human and yeast

   Författare :Avlant Nilsson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; the Crabtree effect; enzyme-constraints; stunting; cellular economy; the Warburg effect; uncoupling; tumor; flux balance analysis; lactate threshold; metabolite depletion;

   Sammanfattning : Growth is the primary objective of the cell. Diseases arise when cells diverge from a healthy growth-pattern. An increased understanding of cellular growth may thus be translated into improved human health. The cell requires materials and free energy (in the form of ATP) in order to grow, metabolism supplies the cell with this. LÄS MER

3. 2. Evolution of Yeast Respiro-Fermentative Lifestyle and the Underlying Mechanisms Behind Aerobic Fermentation

   Författare :Arne Hagman; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Crabtree effect; aerobic fermentation; respiro-fermentation; ethanol production; yeast; central carbon metabolism; evolution of alternative lifestyles;

   Sammanfattning : Under aerobic conditions, most yeasts such as Kluyveromyces lactis, prefer the respiratory pathway and some, such as Saccharomyces cerevisiae prefer less energy efficient fermentative pathway for their energy metabolism. These two metabolic strategies are also known as Crabtree negative and Crabtree positive respectively, and the evolution of the latter has lately been explained by the “make-accumulate-consume” life strategy. LÄS MER

4. 3. Role of embryonic mitochondria in the generation of congenital malformations in diabetic pregnancy

   Författare :Xiaolin Yang; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; embryo; diabetic pregnancy; congenital malformation; mitochondria; high-amplitudemitochondrial swelling; oxygen uptake; glucose utilization; Crabtree effect; superoxide generation; antioxidant; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Sammanfattning : Diabetic pregnancy is associated with an increased incidence of congenital malformations. The teratologicalmechanism may be related to an alteration of embryonic organogenesis by maternal metabolic derangementsduring early gestation. LÄS MER

5. 4. Metabolic Engineering of Central Carbon Metabolism in Saccharomyces cerevisiae The contribution of systems biology to physiological studies

   Författare :Marta Papini; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; fermentation technology; Metabolic engineering; RNA-sequencing; Saccharomyces cerevisiae; DNA microarrays; 13Cbased flux analysis; system biology; Scheffersomyces stipitis;

   Sammanfattning : Saccharomyces cerevisiae is one of the most well characterized yeast of large industrial interest due to several attractivefeatures such as its capability to efficiently convert glucose into ethanol and carbon dioxide at high flux, its amenabilityto genetic modification and the presence of extensive knowledge databases. For these reasons, it is often considered asuitable cell factory for the production of different classes of compounds. LÄS MER

7. 5. Genomics and Evolution Studies of Dekkera bruxellensis, a Wine-Spoilage Yeast

   Författare :Elzbieta Rozpedowska; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Yeasts are unicellular fungi exhibiting a huge diversity of life styles and physiologies and their evolutionary span exceeds the one between mammals and unchordates. The recent advances in genome sequencing and comparative genomics accelerated genomic, evolutionary and physiological studies of yeasts, making them a very promising model to study eukaryotic cell, and also deepened our understanding of the molecular background of yeasts physiologies. LÄS MER