Sökning: "metabolite depletion"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden metabolite depletion.

  1. 1. Constraint-based modeling of metabolism - interpreting predictions of growth and ATP synthesis in human and yeast

    Författare :Avlant Nilsson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; the Crabtree effect; enzyme-constraints; stunting; cellular economy; the Warburg effect; uncoupling; tumor; flux balance analysis; lactate threshold; metabolite depletion;

    Sammanfattning : Growth is the primary objective of the cell. Diseases arise when cells diverge from a healthy growth-pattern. An increased understanding of cellular growth may thus be translated into improved human health. The cell requires materials and free energy (in the form of ATP) in order to grow, metabolism supplies the cell with this. LÄS MER

  3. 2. Exposing the Dark Microbial Biosphere

    Författare :Valerie Hubalek; Stefan Bertilsson; Alexander Eiler; Tim Urich; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Dark biosphere research has been widely neglected, although by volume this biome comprises the lion’s share of habitats on our planet. In these systems the main metabolic strategies are of chemotrophic nature, leading to gradual depletion of redox gradients essential for sustaining life. LÄS MER

  4. 3. Skeletal muscle metabolism in patients with severe chronic obstructive pulmonary disease : A study of carbohydrate and fat metabolism

    Författare :Per Jacobsson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : In chronic obstructive pulmonary disease (COPD) deterioration of skeletal muscle metabolism is reported in both respiratory and non-respiratory muscles. This deterioration may contribute to both the development of respiratory failure and general disability often seen in severe COPD patients. LÄS MER

  5. 4. Purine synthesis inhibition in experimental lupus

    Författare :Charlotte A Jonsson; Göteborgs universitet; []
    Nyckelord :SLE; Mycophenolate mofetil; MRLlpr lpr mice; cytokine; autoantibody;

    Sammanfattning : Systemic lupus erythematosus (SLE) is an autoimmune disease that mainly affects women. The effect of the immune modulating drug mycophenolate mofetil (MMF) on experimental SLE was investigated. LÄS MER

  7. 5. Adrenocorticolysis Induced by 3-MeSO2-DDE : Mechanisms of Action, Kinetics and Species Differences

    Författare :Veronica Lindström; Ingvar Brandt; Ulrika Bergström; Eva Brittebo; Hans Tjälve; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Toxicology; 3-methylsulphonyl-DDE; o; p -DDD; CYP11B1; adrenal cortex; tissue-specific toxicity; bioactivation; kinetics; Y-1 cells; Toxikologi; Biology; Biologi;

    Sammanfattning : The DDT metabolite 3-methylsulphonyl-DDE (3-MeSO2-DDE) induces cell death specifically in the adrenal cortex of mice after a cytochrome P45011B1 (CYP11B1)-catalysed bioactivation. This substance is not only an environmental pollutant, but also a suggested lead compound for an improved chemotherapy of adrenocortical carcinoma (ACC). LÄS MER