Sökning: "superoxide generation"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden superoxide generation.

  1. 1. Superoxide dismutase 1 and cataract

    Författare :Eva Olofsson; Anders Behndig; Stefan Marklund; Marjorie Lou; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cataract; diabetes mellitus; nitric oxide; superoxide; superoxide dismutase; SOD1 null mice; Ophtalmiatrics; Oftalmiatrik; oftalmiatrik; Ophtalmology;

    Sammanfattning : Light and oxygen generate harmful reactive oxygen species (ROS) in the lens, causing biochemical changes that gradually disarrange the lens fibres resulting in light scattering and loss of transparency. In the healthy eye, this chronic exposure to oxidative stress may lead to age-related cataract. LÄS MER

  3. 2. The hyperosmolar airway : Mechanisms of reduced response to nitric oxide

    Författare :Josephine Hjoberg; Uppsala universitet; []
    Nyckelord :Medical sciences; 8-Br-cyclic GMP; airway epithelium; airway reactivity; airway smooth muscle; amiloride; epithelium derived relaxing factor; furosemide; hyperosmolarity; hypertonic saline; nitric oxide; SNAP; sodium chloride; sodium nitroprusside; superoxide; tracheal perfusion; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Clinical Physiology; klinisk fysiologi;

    Sammanfattning : Inhaled nitric oxide (NO) relaxes smooth muscle of the airways and of pulmonary blood vessels and is used to treat lung diseases where the pulmonary vessels are constricted. NO has also been tested as a bronchodilator in asthmatic patients. LÄS MER

  4. 3. Discovery of N-hydroxyguanidines as novel electron acceptors of xanthine oxidase : Potential new drugs for treatment of ischemia and reperfusion injury

    Författare :Maija Dambrova; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; xanthine oxidase; N-hydroxyguanidine derivatives; ischemia and reperfusion; reduction; inhibition; superoxide; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; galenisk farmaci; Pharmaceutics;

    Sammanfattning : Xanthine oxidase (EC 1.1.3.22) is one of the major enzymatic sources of oxygen-derived free radicals. LÄS MER

  5. 4. Radical aspects on arthritis : the role of neutrophil generation of nitric oxide and superoxide in inflammatory conditions

    Författare :Jan Cedergren; Thomas Skogh; Tommy Sundqvist; Tony Forslund; Ingrid Lundberg; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophils; reactive oxygen species; arthritis; NOS; NO; arginase; integrins; Internal medicine; Invärtesmedicin;

    Sammanfattning : The polymorphonuclear neutrophil granulocytes (neutrophils) are gaining renewed interest regarding their involvement in chronic inflammatory disorders, including rheumatoid arthritis (RA). Besides phagocytic and destructive capabilities, neutrophils have regulatory roles, e.g. by influencing responses from dendritic cells and lymphocytes. LÄS MER

  7. 5. Experimental studies on thrombosis and thrombolysis : With special reference to importance of lys-plasminogen, active site thrombin inhibitors and stable fish oil

    Författare :Liying Chen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Thrombolysis; thrombosis; recombinant tissue-type plasminogen activator; lys- and glu-plasminogen; aspirin; thrombin inhibitors; platelets; superoxide dismutase; stable fish oil; Kirurgi; Surgery; Kirurgi; rättsmedicin; Forensic Medicine;

    Sammanfattning : Dissolution and prevention of thrombus in the atherosclerotic coronary artery have become an important part of treatment therapy of acute myocardial infarction. However, the currently most effective thrombolytic agent, recombinant tissue-type plasminogen activator (rt-PA), only elicits 80% recanalization of thrombotically occluded coronary arteries and early occlusion occurs in about 40% of successfullyrecanalized vessels. LÄS MER