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Visar resultat 1 - 5 av 643 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. New Approaches to Studies of Paracellular Drug Transport in Intestinal Epithelial Cell Monolayers

    Författare :Staffan Tavelin; Per Artursson; Staffan Tavelin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; intestinal epithelium; tight junctions; cell culture; Galenisk farmaci; Pharmaceutics; Galenisk farmaci; galenisk farmaci; Pharmaceutics;

    Sammanfattning : Studies of intestinal drug permeability have traditionally been performed in the colon-derived Caco-2 cell model. However, the permeability of these cell monolayers resembles that of the colon rather than that of the small intestine, which is the major site of drug absorption following oral administration. LÄS MER

  3. 2. Varför får jag icke följa med dit fram? : Medborgarskapet och den offentliga debatten om dövstumma och blinda 1860–1914

    Författare :Staffan Bengtsson; Staffan Förhammar; Marie C. Nelsson; Svenbjörn Kilander; Linköpings universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Citizenship; disability; social policy; social categorisation; social recognition; gender; Disability research; Handikappsforskning;

    Sammanfattning : Different kinds of cultural studies can be used in order to learn more about disability, social policies, attitudes and citizenship. The purpose of this study is to outline some aspects of disability and Swedish society during the 19th century. The ambition is to analyse the issue of the integration of the deaf-mutes and the blind. LÄS MER

  4. 3. Workpiece steels protecting cutting tools from wear : A study of the effects of alloying elements on material transfer and coating damage mechanisms

    Författare :Toshiharu Aiso; Staffan Jacobson; Urban Wiklund; Staffan Söderberg; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Metal cutting; Steel; Cutting tools; Transfer; Coating; Sliding; Teknisk fysik med inriktning mot tribomaterial; Engineering Science with specialization in Tribo Materials;

    Sammanfattning : The vision of this thesis is to improve the machinability of workpiece steels. Workpiece material frequently transfers to the cutting tools during machining, and the transfer layers then forming on the tools may give both good and bad effects on machining performance and tool life. LÄS MER

  5. 4. Interorganizational IT Support for Collaborative Product Development

    Författare :Anna Öhrwall Rönnbäck; Staffan Brege; Staffan Gullander; Linköpings universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Collaborative Product Development; Interorganizational Information Systems IOIS ; Business Relationships; Buyer-Supplier Dyads; Supplier Networks; Produktutveckling; Informationssystem; Kundkontakter;

    Sammanfattning : As product complexity increases and markets become more global, companies tend to collaborate with customers, suppliers and partners in business process activities previously carried out within a single firm. This is observed notably also in product development. LÄS MER

  7. 5. Generating new models to study propagation and pathology of alpha-synuclein in Parkinson's disease and multiple system atrophy

    Författare :Staffan Holmqvist; Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Synucleinopthies are neurodegenerative diseases characterised by the formation of α-synuclein-rich intracellular inclusions in neurons and glia. Traditionally, animalmodels and immortalized cell lines have been used to investigate why and how theseinclusions form, and how they impact on cellular function. LÄS MER