Sökning: "sialic acid"

Visar resultat 21 - 25 av 53 avhandlingar innehållade orden sialic acid.

  1. 21. Structural and Functional Studies of Membrane Proteins For Future Development of Antimicrobial Drugs

    Författare :Elin Dunevall; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Sialic acid transporters; SiaT; MraY; Tunicamycin; Antibiotic resistance;

    Sammanfattning : Antibiotic resistance is a world-wide occurring problem which threatens human health. Without development of any new and effective antibiotics, the rapid growth of antibiotic-resistant bacterial infections could put society in a situation resembling the pre-antibiotic era when a simple lung infection could kill a human being. LÄS MER

  3. 22. α1-acid glycoprotein modulates the function of human neutrophils and platelets

    Författare :Peter Gunnarsson; Magnus Grenegård; Henrik Thorlacius; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The acute-phase protein α1-acid glycoprotein (AGP; orosomucoid) was initially identified andcharacterised in the 1950s. The normal plasma concentration is around 0.5-1 mg/ml butduring inflammation the concentration increase several fold and the carbohydrate compositionof the protein changes. LÄS MER

  4. 23. Novel imaging technology and tools for biomarker detection in cancer

    Författare :Zahra El-Schich; Malmö högskola; []
    Nyckelord :Biomarkers; Kronisk lymfatisk leukemi; Early detection of cancer; Diagnosis; Leukemia; Lymphocytic; Chronic; B-Cell; Apoptosis; Digital holografi;

    Sammanfattning : Cancer is a leading cause of death worldwide. Normally the balance betweencell growth and cell death is strongly controlled. Chronic lymphocytic leukemiais an indolent disease that has a highly variable clinical course and is the mostcommon hematological malignancy amongst adults in the Western countries. LÄS MER

  5. 24. Biolubrication: Structural investigation of lubricin and its glycosylation

    Författare :Liaqat Ali; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lubricin; mass spectrometry; EPAPTTPK; GALNTs; biolubricator;

    Sammanfattning : The sliding articular cartilage surfaces of the human diarthrodial joints are surrounded by biolubricating synovial fluid (SF), creating a perfect low friction biological biobearing structure with excellent lubrication and wear resistance, even during motion. Lubrication is predominately provided by surface adhered biomolecules including phospholipids, hyaluronic acid and synovial lubricin. LÄS MER

  7. 25. Antigens derived from the mucin MUC1 : Solution and solid-phase synthesis of saccharides, peptides and glycopeptides

    Författare :Maciej Pudelko; Mikael Elofsson; Fredrik Almqvist; Thisbe K. Lindhorst; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lactones; glycopeptides; signal peptide; neoglycolipid arrays; solid-phase synthesis; MUC1; gel-phase 19F NMR spectroscopy; fluorinated alpha-amino protective group; Organic chemistry; Organisk kemi;

    Sammanfattning : Mucin is a term used to describe a large family of heavily glycosylated proteins which are present on the surfaces of secretory epithelial cells and are overexpressed by many carcinomas. Membrane-bound mucin MUC1 is of special interest. Its backbone consists of repeating units of twenty amino acids with five potential glycosylation sites. LÄS MER