Sökning: "sialic acid"
Visar resultat 6 - 10 av 53 avhandlingar innehållade orden sialic acid.
6. Design, synthesis and evaluation of bacterial sialic acid uptake inhibitors
Sammanfattning : Antibiotic resistance is a major threat for our society and finding novel antibacterial therapies is of greatimportance. In this thesis, we investigate bacterial sialic acid uptake inhibitors as a novel antibacterial approach.Bacteria do not biosynthesise sialic acid and therefore harvest it from the host. LÄS MER
7. Design and Synthesis of Sialic Acid Conjugates as Inhibitors of EKC-causing Adenoviruses
Sammanfattning : The combat against viral diseases has been, and still is, a major challenge in the field of drug development. Viruses are intracellular parasites that use the host cell ma-chinery for their replication and release. Therefore it is difficult to target and destroy the viral particle without disturbing the essential functions of the host cell. LÄS MER
8. Tailored conjugates of N-acetylneuraminic acid and small molecules that block virus cell attachment and entry
Sammanfattning : Viruses are obligate intracellular parasites, unable to replicate without exploiting machinery andmaterials from host cells. Pandemics of viral diseases have had large impacts on human socieities and are continued threats to global health. LÄS MER
9. Sialic acid-dependent binding specificities of Helicobacter pylori and influenza virus. Importance of different parts of the binding sequences
Sammanfattning : Many viruses and bacteria adhere to host cell glycoconjugates in a specific manner, utilizing selected carbohydrate sequences. The aim of this work was to investigate at a molecular level the interactions of two important human pathogens, influenza virus and Helicobacter pylori, with sialylated carbohydrate structures. LÄS MER
10. Sialic acid : a new potential marker of alcohol abuse
Sammanfattning : Biological markers have been used for several years to detect heavy alcohol consumption or organ damage induced by alcohol. Early identification of alcohol abuse or alcohol dependence could increase the likelihood of early treatment, thereby reducing health damage and health care costs. LÄS MER