Sökning: "sialic acid"

Visar resultat 11 - 15 av 53 avhandlingar innehållade orden sialic acid.

  1. 11. Glycoconjugates : synthesis and investigation of carbohydrate-protein interactions

    Författare :Sara Spjut; Mikael Elofsson; Ulf Ellervik; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glycoconjugates; Carbohydrates; Galactose; Glucose; Solid-phase synthesis; SPOS; Glycosylation; Gel-phase 19F NMR spectroscopy; Fluorinated linker; Carbohydrate array; Microtiter plates; Carbohydrate-protein interactions; carbamate linker; Fsec; Protecting group; Fluorinated protecting group; Multivalent glycoconjugates; Adenovirus; Ad37; Epidemic keratoconjunctivitis; EKC; Sialic acid; Adenovirus inhibitor; Trivalent; Tetravalent; X-ray crystal structure; Bioorganic chemistry; Bioorganisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : To study the functions of glycoconjugates in biological systems reliable and efficient protocols for glycoconjugate synthesis are needed. To reach this goal we have developed methods for solid-phase synthesis of glycoconjugates that can be monitored with gel-phase 19F spectroscopy using fluorinated linkers, building blocks, and protecting groups. LÄS MER

  3. 12. Capsid protein functions of enteric human adenoviruses

    Författare :Anandi Rajan; Niklas Arnberg; Stefan Schwartz; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenovirus; gastroenteritis; capsid proteins; receptor; integrins; heparan sulfate; sialic acid;

    Sammanfattning : Human adenoviruses (HAdVs) cause respiratory illnesses, epidemic conjunctivitis and infantile gastroenteritis. HAdV types 40 and 41 cause enteric infections in infants worldwide. HAdVs use various receptors for attachment onto different host cells. LÄS MER

  4. 13. Moleculary imprinted micro- and nanoparticles for cancer associated glycan motifs

    Författare :Liliia Mavliutova; Börje Sellergren; Michael Whitcombe; Malmö universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Moleculary imprinted polymer; sialic acid; glycan recognition; synthetic receptor;

    Sammanfattning : Sialic acids are an important family of monosaccharides that are typically found as terminal moieties of glycans. Aberrant sialylation has been proven to correlate with various diseases including cancer. Glycosylation analysis is complex due to high diversityof the glycan isomers and their low abundance. LÄS MER

  5. 14. Galectin-8 specificity to cells: from broad outside to fine inside

    Författare :Susanne Nordenfelt; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedical sciences; Biomedicinska vetenskaper; Intracellular targeting; Sialic acid; Galectin fine specificity;

    Sammanfattning : Glycobiology is the world of sugars: how they are made, what they look like, and what they do. Despite the importance of glycan structures in life, knowledge has been hampered due to their inherent complexity. LÄS MER

  7. 15. The glycobiology of human adenovirus infections : implications for tropism and treatment

    Författare :Naresh Chandra; Niklas Arnberg; Lars Frängsmyr; Gunnel Haldén; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; denovirus; cellular receptor; glycosaminoglycan; sialic acid; decoy receptors; tropism; epidemic keratoconjunctivitis; antiviral drugs; GAG-mimetic; obesity; medicinsk virologi; Medical Virology;

    Sammanfattning : Human adenoviruses (HAdVs) are common human pathogens, causing gastrointestinal, ocular, and respiratory infections on a regular basis. Epidemic keratoconjunctivitis (EKC) is a severe ocular infection for which no approved antivirals are available. LÄS MER