Sökning: "Lactones"

Visar resultat 1 - 5 av 36 avhandlingar innehållade ordet Lactones.

  1. 1. Antigens derived from the mucin MUC1 : Solution and solid-phase synthesis of saccharides, peptides and glycopeptides

    Författare :Maciej Pudelko; Mikael Elofsson; Fredrik Almqvist; Thisbe K. Lindhorst; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lactones; glycopeptides; signal peptide; neoglycolipid arrays; solid-phase synthesis; MUC1; gel-phase 19F NMR spectroscopy; fluorinated alpha-amino protective group; Organic chemistry; Organisk kemi;

    Sammanfattning : Mucin is a term used to describe a large family of heavily glycosylated proteins which are present on the surfaces of secretory epithelial cells and are overexpressed by many carcinomas. Membrane-bound mucin MUC1 is of special interest. Its backbone consists of repeating units of twenty amino acids with five potential glycosylation sites. LÄS MER

  3. 2. Biological Activities of Natural and Semi-Synthetic Pseudo-Guaianolides: Inhibition of Transcription Factors

    Författare :Rodrigo Villagomez; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; pseudo-guaianolides; sesquiterpene lactones; NF-κB;

    Sammanfattning : Damsin (1) is a natural sesquiterpene lactone (SL) isolated from Ambrosia arborescens Mill., a plant used in the Andes as antiinflammatory medicine. LÄS MER

  4. 3. Exploring evolutionary and chemical space using chemoinformatic tools and traditional methods in pharmacognosy

    Författare :Astrid Henz Ryen; Anders Backlund; Thierry Kogej; Fernando B. Da Costa; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; angiosperm chemistry; physicochemical properties of plant specialized metabolites; chemical diversity; chemical space; sesquiterpene lactones; scaffold diversity; molecular framework; cluster analysis; ECFP6; Lindera benzoin; sesquiterpenes; anti-inflammatory; Farmakognosi; Pharmacognosy;

    Sammanfattning : The number of new drugs coming to the market is declining while interest in lead discovery from natural resources is seeing a revival. Although methods for isolation and identification of natural products have advanced tremendously, methods for selection of potential leads have fallen behind. LÄS MER

  5. 4. Phylogenies and Secondary Chemistry in Arnica (Asteraceae)

    Författare :Catarina Ekenäs; Katarina Andreasen; Anders Backlund; Lynn Bohs; Uppsala universitet; []
    Nyckelord :Biology; phylogeny; ITS; ETS; RPB2; sesquiterpene lactones; PCA; bioassay; NF-κB; neutrophil; chloroplast; Biologi; Arnica; Asteraceae;

    Sammanfattning : The genus Arnica (Asteraceae) was investigated for phylogenetic relationships and sesquiterpene lactone (STL) content with the aims to trace the evolutionary history of the genus and to investigate possible congruencies between DNA sequence data, secondary chemistry, and biological activity. Complex evolutionary patterns in Arnica are evident from phylogenetic analyses of chloroplast regions (the rpl16 and rps16 introns and the psbA–trnH, ycf4–cemA, and trnT–L spacers), nuclear ribosomal regions (the internal and external transcribed spacers) and the nuclear low-copy DNA region coding for the second largest subunit of RNA polymerase II (RPB2) between exons 17 and 23. LÄS MER

  7. 5. Thiol−ene Coupling of Renewable Monomers : at the forefront of bio-based polymeric materials

    Författare :Mauro Claudino; Mats K. G. Johansson; Mats Jonsson; Anna Wistrand; Sven Göthe; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Thiol-ene chemistry; monounsaturated fatty-acids; renewable resources; cis trans-isomerization; photopolymerization; networks; polyesters; thermal viscoelastic properties; thin-films; unsaturated macro lactones; coatings;

    Sammanfattning : Plant derived oils bear intrinsic double-bond functionality that can be utilized directly for the thiol–ene reaction. Although terminal unsaturations are far more reactive than internal ones, studies on the reversible addition of thiyl radicals to 1,2-disubstituted alkenes show that this is an important reaction. LÄS MER