Sökning: "gel-phase 19F NMR spectroscopy"

Hittade 5 avhandlingar innehållade orden gel-phase 19F NMR spectroscopy.

1. 1. Solid-phase glycoconjugate synthesis : on-resin analysis with gel-phase ¹9F NMR spectroscopy

   Författare :Mickael Mogemark; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Solid-phase synthesis; protective groups; linkers; monitoring; gel-phase; 19F NMR spectroscopy; carbohydrates; oligosaccharides; glycopeptides; Organisk kemi; Organic chemistry; Organisk kemi;

   Sammanfattning : An efficient and versatile non-destructive method to analyze the progress of solid-phase glycoconjugate synthesis with gel-phase 19F NMR spectroscopy is described. The method relies on use of fluorinated linkers and building blocks carrying fluorinated protective groups. LÄS MER

3. 2. Antigens derived from the mucin MUC1 : Solution and solid-phase synthesis of saccharides, peptides and glycopeptides

   Författare :Maciej Pudelko; Mikael Elofsson; Fredrik Almqvist; Thisbe K. Lindhorst; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lactones; glycopeptides; signal peptide; neoglycolipid arrays; solid-phase synthesis; MUC1; gel-phase 19F NMR spectroscopy; fluorinated alpha-amino protective group; Organic chemistry; Organisk kemi;

   Sammanfattning : Mucin is a term used to describe a large family of heavily glycosylated proteins which are present on the surfaces of secretory epithelial cells and are overexpressed by many carcinomas. Membrane-bound mucin MUC1 is of special interest. Its backbone consists of repeating units of twenty amino acids with five potential glycosylation sites. LÄS MER

4. 3. Glycoconjugates : Solid-phase synthesis and biological applications

   Författare :Fredrik Wallner; Mikael Elofsson; Jan Kihlberg; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glycoconjugate; Glycolipid; Solid-phase synthesis; Glycosylation; Gel-phase 19F-NMR spectroscopy; Fluorinated linker; Carbohydrat array; CD1; Organic chemistry; Organisk kemi;

   Sammanfattning : Glycoconjugates are biologically important molecules with diverse functions. They consist of carbohydrates of varying size and complexity, attached to a non-sugar moiety as a lipid or a protein. Glycoconjugate structures are often very complex and their intricate biosynthetic pathways makes overexpression difficult. LÄS MER

5. 4. Combinatorial Synthesis of Pilicides

   Författare :Anette Svensson; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; gel-phase 19F NMR spectroscopy; fluorinated linkers; E. coli bacteria; pilicides; combinatorial chemistry; solid-phase synthesis; Organic chemistry; Organisk kemi;

   Sammanfattning : This thesis describes a combinatorial approach to design and synthesis of three libraries of compounds, referred to as pilicides, designed to target periplasmic chaperones present in uropathogenic Escherichia coli bacteria that are the main cause of urinary tract infections. Periplasmic chaperones are required for assembly of adhesive organelles, i. LÄS MER

7. 5. Glycoconjugates : synthesis and investigation of carbohydrate-protein interactions

   Författare :Sara Spjut; Mikael Elofsson; Ulf Ellervik; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glycoconjugates; Carbohydrates; Galactose; Glucose; Solid-phase synthesis; SPOS; Glycosylation; Gel-phase 19F NMR spectroscopy; Fluorinated linker; Carbohydrate array; Microtiter plates; Carbohydrate-protein interactions; carbamate linker; Fsec; Protecting group; Fluorinated protecting group; Multivalent glycoconjugates; Adenovirus; Ad37; Epidemic keratoconjunctivitis; EKC; Sialic acid; Adenovirus inhibitor; Trivalent; Tetravalent; X-ray crystal structure; Bioorganic chemistry; Bioorganisk kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : To study the functions of glycoconjugates in biological systems reliable and efficient protocols for glycoconjugate synthesis are needed. To reach this goal we have developed methods for solid-phase synthesis of glycoconjugates that can be monitored with gel-phase 19F spectroscopy using fluorinated linkers, building blocks, and protecting groups. LÄS MER